International Journal of Infectious Diseases
Volume 11, Issue 2 , Pages 129-136 , March 2007

A fully liquid diphtheria–tetanus–five component acellular pertussis–inactivated poliomyelitis–Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants

  • Tzou Yien Lin

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Ying-Hsiang Wang

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Luan-Yin Chang

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Yhu-Chering Huang

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Hsiu-Tsun Kao

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Pen-Yi Lin

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Hsiao-Kuo Lu

      Affiliations

    • Chang-Gung Children's Hospital, Taoyuan, Taiwan
    • ,
  • Pascale Chavand

      Affiliations

    • Medical Affairs International, Sanofi Pasteur International, 2, avenue Pont Pasteur, 69007 Lyon, France
    • ,
  • Esteban Ortiz

      Affiliations

    • Medical Affairs International, Sanofi Pasteur International, 2, avenue Pont Pasteur, 69007 Lyon, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 4 3737 7258; fax: +33 4 3737 7171.

Received 3 June 2005 ,Revised 6 October 2005 ,Accepted 25 October 2005.

References 

  1. Edwards KM, Decker MD. Pertussis vaccine. In:  Plotkin SA,  Orenstein WA editor. Vaccines. 4th ed.. Philadelphia, Pa: Saunders; 2004;p. 471–528
  2. Edwards K, Meade B, Decker M, Reed GF, Rennels MB, Steinhoff MC, et al. Comparison of 13 acellular pertussis vaccines: overview and serologic response. Pediatrics. 1995;96:548–557
  3. Decker MD, Edwards KM, Steinhoff MC, Rennels MB, Pichichero ME, Englund JA, et al. Comparison of 13 acellular pertussis vaccines: adverse reactions. Pediatrics. 1995;96:557–566
  4. Gustafsson L, Hallander H, Olin P, Reizenstein E, Storsaeter J. A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med. 1996;334:349–355
  5. Olin P, Rasmussen F, Gustafsson L, Hallander HO, Heijbel H. Randomised controlled trial of two-component, three component, and five component acellular pertussis vaccines compared with whole-cell pertussis vaccine. Lancet. 1997;350:1569–1577
  6. Mills E, Gold R, Thipphawong J, Barreto L, Guasparini R, Meekison W, et al. Safety and immunogenicity of a combined five-component pertussis–diphtheria–tetanus–inactivated poliomyelitis–Haemophilus B conjugate vaccine administered to infants at two, four and six months of age. Vaccine. 1998;16:576–585
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  8. Eskola J, Ölander RM, Hovi T, Litmanen L, Peltola S, Kayhty H. Randomized trial of the effect of co–administration with acellular pertussis DTP vaccine on immunogenicity of Haemophilus influenzae type b conjugate vaccine. Lancet. 1996;348:1688–1692
  9. Eskola J, Ward J, Dagan R, Goldblatt D, Zepp F, Siegrist CA. Combined vaccination of Haemophilus influenzae type b conjugate and diphtheria–tetanus–pertussis containing acellular pertussis. Lancet. 1999;354:2063–2068
  10. Pichichero ME, Latiolais T, Bernstein DI, Hosbach P, Christian E, Vidor E, et al. Vaccine antigen interactions after a combination diphtheria–tetanus toxoid–acellular pertussis/purified capsular polysaccharide of Haemophilus influenzae type b–tetanus toxoid vaccine in two-, four- and six-month infants. Pediatr Infect Dis J. 1997;16:863–870
  11. Käyhty H, Peltola H, Karanko V, Mäkelä PH. The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. J Infect Dis. 1983;147:1100
  12. Anderson P. The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b. J Infect Dis. 1984;149:1034–1035
  13. Lee CY, Thipphawong J, Huang LM, Lee PI, Chiu HH, Lin W, et al. An evaluation of the safety and immunogenicity of a five-component acellular pertussis, diphtheria, and tetanus toxoid vaccine (DTaP) when combined with a Haemophilus influenzae type b–tetanus toxoid conjugate vaccine (PRP–T) in Taiwanese infants. Pediatrics. 1999;103:25–30
  14. Scheifele D, Halperin S, Law B, King A. Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada. CMAJ. 2005;172:53–56
  15. Le Saux N, Barrowman NJ, Moore DL, Whiting S, Scheifele D, Halperin S. Decrease in hospital admissions for febrile seizures and reports of hypotonic–hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT. Pediatrics. 2003;112:348–353

☆ Presented at the 11th International Congress on Infectious Diseases, Cancun, Mexico, March 5–7, 2004 as “Immunogenicity and safety of a fully liquid DTaP–IPV–Hib vaccine given as a three-dose primary vaccination in Taiwanese infants”.

PII: S1201-9712(06)00057-9

doi: 10.1016/j.ijid.2005.10.014

International Journal of Infectious Diseases
Volume 11, Issue 2 , Pages 129-136 , March 2007

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