International Journal of Infectious Diseases
Volume 11, Issue 2 , Pages 161-165 , March 2007

Prophylactic effect of the anti-inflammatory drug diclofenac in experimental schistosomiasis mansoni

  • Nevine Guirguis Nessim

      Affiliations

    • Corresponding Author InformationCorresponding author. Current address: c/o Habib El Masry, Dar Consultants, POB 895 Cairo, 11511 Egypt. Tel.: +20 2 7363228; fax: +20 2 3461170.
    • ,
  • Soheir Mahmoud

Received 11 September 2005 ,Revised 20 December 2005 ,Accepted 5 January 2006.

References 

  1. Utzinger J, Xiao S, N’Goran EK, Bergquist R, Tanner M. The potential of artemether for the control of schistosomiasis. Int J Parasitol. 2001;31:1549–1562
  2. Sangster NC. Managing parasiticide resistance. Vet Parasitol. 2001;98:89–109
  3. Ojewole JA, Adewunmi CO. Anti-inflammatory and hypoglycaemic effects of Tetrapleura tetraptera (Taub) (Fabacaea) fruit aqueous extracts in rats. J Ethnopharmacol. 2004;2–3:177–182
  4. Farag MM, Salama MA, Abou-Basha L. Experimental murine schistosomiasis reduced hepatic morbidity after pre and post-infection treatment with ibuprofen or diclofenac sodium. Ann Trop Med Parasitol. 1995;497–504
  5. Nessim NG, Hassan SI, William S, El Baz H. Effect of the broad spectrum anthelmintic drug flubendazole upon Schistosoma mansoni experimentally infected mice. Arzneimittelforschung/Drug Research. 2000;50:1129–1133
  6. Duvall RH, De Witt WB. An important perfusion technique for recovering adult schistosomes from laboratory animals. Am J Trop Med Hyg. 1967;16:483–486
  7. Harris HF. On the rapid conversion of haematoxylin into haematin staining reactions. J App Mic Lab Methods. 1900;3:777

    Quoted from: Arzneim Forsch/Drug Res 2003;53:440–4 Treatment of acute schistosomiasis mansoni with praziquantel and an antifibrotic agent in mice.

  8. Giboda M, Jacobs P, Smith JM, Miller SC. Immune response of mice infected with Schistosoma mansoni is modulated by antifibrotic treatment. Ann Trop Med Parasitol. 1995;89:415–429
  9. Hassan SI, Aly I, Guirguis N, Amer M. Resistance to challenge in mice with chronic Schistosoma mansoni treated with praziquantel and an antifibrotic agent. Kasr El Eini Medical Journal. 2004;10:213–219

    Quoted from: Arzneim Forsch/Drug Res 2003;53:440–444. Treatment of acute schistosomiasis mansoni with praziquantel and an antifibrotic agent in mice.

  10. Mansy SS, Yehia HA, Hassan MM, Hassan EA, Youssef MM, Abdel Hadi AA, et al. Octreotide decreases connective tissue formation and improves vascular changes associated with hepatic schistosomiasis. J Egypt Soc Parasitol. 1998;28:23–44
  11. Badawy AA, El-Badrawy NM, Hassan MM, Ebeid FA. Colchicine therapy for hepatic murine schistosomal fibrosis: image analysis and serological study. Int J Exp Path. 1999;80:25–34
  12. Hesse M, Cheever AW, Jankovic D, Wynn TA. NOS-2 mediates the protective anti-inflammatory and antifibrotic effect of the Th-1 inducing adjuvant, IL-2, in a Th2 model of granulomatous disease. Am J Pathol. 2000;157:945–995
  13. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med. 2001;345:517–525
  14. Botros SS, El Badrawy N, Metwally AA, Khayyal MT. Study of some immunopharmacological properties of praziquantel in experimental schistosomiasis mansoni. Ann Trop Med Parasitol. 1986;80:189–196
  15. Hassan SI, Botros SS, El Nahhal HM, Azab ME, Shaker ZA, El-Garem AA. Effect of specific chemotherapy on the immune response and resistance to reinfection in experimental Schistosoma mansoni. Int J Immunopharmacol. 1990;12:207–215
  16. Pancera CF, Alves AL, Paschoalotti MA, Chieffi PP. Effect of wide spectrum drugs upon Schistosoma mansoni infected mice. Rev Inst Med Trop S Paulo. 1979;39:159–163
  17. Chatterjee S, Van Marck E. The role of somatostatin in schistosomiasis: a basis for immunomodulation in host-parasite interactions. Trop Med Int Health. 2001;6:578–581
  18. Doenhoff MJ, Stanley RG, Pryce D, Curtis RC, Parry H, Griffiths K, et al. Identification of a fibrinolytic enzyme in Schistosoma mansoni eggs and modulated blood fibrinogen metabolism in S. mansoni-infected mice. Parasitology. 2003;126:231–234
  19. Pyrrho AS, Lenzi HL, Ramos JA, Moura-Neto R, Cachem FC, Santos da Silva C, et al. Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis. Parasitol Res. 2004;92:478–483

PII: S1201-9712(06)00065-8

doi: 10.1016/j.ijid.2006.01.004

International Journal of Infectious Diseases
Volume 11, Issue 2 , Pages 161-165 , March 2007

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