International Journal of Infectious Diseases
Volume 12, Issue 4 , Pages 374-379 , July 2008

Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality

  • Mustafa A. Çevik

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    • ,
  • Ayse Erbay

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 4305464; fax: +90 312 4305393.
    • ,
  • Hürrem Bodur

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    • ,
  • Evrim Gülderen

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    • ,
  • Aliye Baştuğ

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    • ,
  • Ayhan Kubar

      Affiliations

    • Department of Virology, Gulhane Military Medical Academy, Ankara, Turkey
    • ,
  • Esragül Akıncı

      Affiliations

    • Infectious Diseases and Clinical Microbiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey

Received 22 May 2007 ,Revised 16 August 2007 ,Accepted 25 September 2007.

References 

  1. Frangoulidis D, Meyer H. Measures undertaken in the German Armed Forces Field Hospital deployed in Kosovo to contain a potential outbreak of Crimean-Congo hemorrhagic fever. Mil Med. 2005;170:366–369
  2. Drosten C, Minnak D, Emmerich P, Schmitz H, Reinicke T. Crimean-Congo hemorrhagic fever in Kosovo. J Clin Microbiol. 2002;40:1122–1123
  3. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, et al. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect. 2004;10:1040–1055
  4. Andersson I, Bladh L, Mousavi-Jazi M, Magnusson KE, Lundkvist A, Haller O, et al. Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. J Virol. 2004;78:4323–4329
  5. Burt FJ, Leman PA, Smith JF, Swanepoel R. The use of a reverse transcription-polymerase chain reaction for the detection of viral nucleic acid in the diagnosis of Crimean-Congo hemorrhagic fever. J Virol Methods. 1998;70:129–137
  6. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. The characteristics of Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and the impact of oral ribavirin therapy. Clin Infect Dis. 2004;39:285–289
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  11. Schwarz TF, Nsanze H, Ameen AM. Clinical features of Crimean-Congo haemorrhagic fever in the United Arab Emirates. Infection. 1997;25:364–367
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  13. Ozkurt Z, Kiki I, Erol S, Erdem F, Yilmaz N, Parlak M, et al. Crimean-Congo hemorrhagic fever in Eastern Turkey: clinical features, risk factors and efficacy of ribavirin therapy. J Infect. 2006;52:207–215
  14. Ergonul O, Celikbas A, Baykam N, Eren S, Dokuzoguz B. Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited. Clin Microbiol Infect. 2006;12:551–554
  15. Athar MN, Baqai HZ, Ahmad M, Khalid MA, Bashir N, Ahmad AM, et al. Short report: Crimean-Congo hemorrhagic fever outbreak in Rawalpindi, Pakistan, February 2002. Am J Trop Med Hyg. 2003;69:284–287
  16. Shepherd AJ, Swanepoel R, Leman PA. Antibody response in Crimean–Congo hemorrhagic fever. Rev Infect Dis. 1988;11(Suppl 4):S801–S806
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  18. Tang Q, Saijo M, Zhang Y, Asiguma M, Tianshu D, Han L, et al. A patient with Crimean–Congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems. Clin Diagn Lab Immunol. 2003;10:489–491
  19. Mardani M, Jahromi MK, Naieni KH, Zeinali M. The efficacy of oral ribavirin in the treatment of Crimean–Congo hemorrhagic fever in Iran. Clin Infect Dis. 2003;36:1613–1618
  20. Vasilenko SM, Vassilev TL, Bozadjiev LG, Bineva IL, Kazarov GZ. Specific intravenous immunoglobulin for Crimean–Congo haemorrhagic fever. Lancet. 1990;335:791–792

PII: S1201-9712(07)00199-3

doi: 10.1016/j.ijid.2007.09.010

International Journal of Infectious Diseases
Volume 12, Issue 4 , Pages 374-379 , July 2008

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