International Journal of Infectious Diseases
Volume 13, Issue 4 , Pages 483-487 , July 2009

Pharmacodynamic target attainment potential of azithromycin, clarithromycin, and telithromycin in serum and epithelial lining fluid of community-acquired pneumonia patients with penicillin-susceptible, intermediate, and resistant Streptococcus pneumoniae

  • Ayman M. Noreddin

      Affiliations

    • College of Pharmacy, University of Minnesota, 1110 Kirby Dr., Duluth, MN 55812, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 218 726 6028; fax: +1 218 726 6500.
    • ,
  • Walid F. El-Khatib

      Affiliations

    • College of Pharmacy, University of Minnesota, 1110 Kirby Dr., Duluth, MN 55812, USA
    • Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt
    • ,
  • Jason Aolie

      Affiliations

    • College of Pharmacy, University of Minnesota, 1110 Kirby Dr., Duluth, MN 55812, USA
    • ,
  • Ahmed H. Salem

      Affiliations

    • College of Pharmacy, University of Minnesota, 1110 Kirby Dr., Duluth, MN 55812, USA
    • Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt
    • ,
  • George G. Zhanel

      Affiliations

    • Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Received 25 May 2008 ,Revised 31 July 2008 ,Accepted 15 August 2008.

  • Image Result

    Probability of attainment of the fAUC0–24/MIC90 target of 30 for azithromycin, clarithromycin, and telithromycin in the serum of community-acquired pneumonia patients with penicillin-susceptible (PS),

    Probability of attainment of the fAUC0–24/MIC90 target of 30 for azithromycin, clarithromycin, and telithromycin in the serum of community-acquired pneumonia patients with penicillin-susceptible (PS), penicillin-intermediate (PI), and penicillin-resistant (PR) Streptococcus pneumoniae.

  • Image Result
    Probability of attainment of the fAUC0–24/MIC90 target of 30 for azithromycin, clarithromycin, and telithromycin in the epithelial lining fluid of community-acquired pneumonia patients with penicillin

    Probability of attainment of the fAUC0–24/MIC90 target of 30 for azithromycin, clarithromycin, and telithromycin in the epithelial lining fluid of community-acquired pneumonia patients with penicillin-susceptible (PS), penicillin-intermediate (PI), and penicillin-resistant (PR) Streptococcus pneumoniae.

☆ This study was presented at the International Society of Chemotherapy Third International Conference on Community Acquired Pneumonia (ISC-CAP), April 14–16, 2007, Montreal, Quebec, Canada.

PII: S1201-9712(08)01540-3

doi: 10.1016/j.ijid.2008.08.016

International Journal of Infectious Diseases
Volume 13, Issue 4 , Pages 483-487 , July 2009

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