International Journal of Infectious Diseases
Volume 13, Issue 5 , Pages 584-588 , September 2009

High prevalence of β-lactam-resistant Haemophilus influenzae type b isolates derived from respiratory tract specimens in Japanese patients

  • Shin-ichi Yokota

      Affiliations

    • Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan
    • ,
  • Yasuo Ohkoshi

      Affiliations

    • Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan
    • Hokkaido Laboratory, SRL Co., Ltd, Chuo-ku, Sapporo, Japan
    • ,
  • Kiyoshi Sato

      Affiliations

    • Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan
    • ,
  • Nobuhiro Fujii

      Affiliations

    • Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 11 611 2111; fax: +81 612 5861.

Received 13 March 2008 ,Revised 8 September 2008 ,Accepted 11 September 2008.

References 

  1. Saito A, Kohno S, Matsushima T, Watanabe A, Oizumi K, Yamaguchi K, et al. Prospective multicenter study of the causative organisms of community-acquired pneumonia in adults in Japan. J Infect Chemother. 2006;12:63–69
  2. Suzuki K, Nishimura T, Baba S. Current status of bacterial resistance in the otolaryngology field: results from the Second Nationwide Survey in Japan. J Infect Chemother. 2003;9:46–52
  3. Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K, Takeuchi Y, et al. Association of amino acid substitutions in penicillin-binding protein 3 with β-lactam resistance in β-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001;45:1693–1699
  4. Tristram S, Jacobs MR, Appelbaum PC. Antimicrobial resistance in Haemophilus influenzae. Clin Microbiol Rev. 2007;20:368–389
  5. Sanbongi Y, Suzuki T, Osaki Y, Senju N, Ida T, Ubukata K. Molecular evolution of β-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan. Antimicrob Agents Chemother. 2006;50:2487–2492
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  9. Hasegawa K, Yamamoto K, Chiba N, Kobayashi R, Nagai K, Jacobs MR, et al. Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States. Microb Drug Resist. 2003;9:39–46
  10. Falla TJ, Crook DW, Brophy LN, Maskell D, Kroll JS, Moxon ER. PCR for capsular typing of Haemophilus influenzae. J Clin Microbiol. 1994;32:2382–2386
  11. Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. M07-A7 approved standard. 7th ed. Wayne, PA: CLSI; 2006.
  12. Ohkoshi Y, Yokota S, Sato K, Hayashi T, Matsuda K, Kuwahara O, et al. Antibiotic susceptibility of Haemophilus influenzae strains isolated from various clinical sources in Hokkaido Prefecture, Japan. J Infect Chemother. 2008;14:93–98
  13. Ubukata K, Kobayashi R, Chiba N, Hasegawa K, Konno M. Surveillance based on molecular epidemiology for Streptococcus pneumoniae isolates between 1998 and 2000 in Japan—results of clinical isolates collected by the Community-Acquired Bacterial Infections Working Group [In Japanese]. Jpn J Chemother. 2003;51:60–70
  14. Luong DC, Ishiwada N, Takeda N, Kohno Y. Serotypes of Haemophilus influenzae strains isolated from pediatric patients with respiratory tract infections. Tohoku J Exp Med. 2004;202:245–254
  15. Hasegawa K, Chiba N, Kobayashi R, Murayama SY, Iwata S, Sunakawa K, et al. Rapidly increasing prevalence of β-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae type b in patients with meningitis. Antimicrob Agents Chemother. 2004;48:1509–1514
  16. Hasegawa K, Kobayashi R, Takada E, Ono A, Chiba N, Morozumi M, et al. High prevalence of type b β-lactamase-non-producing ampicillin-resistant Haemophilus influenzae in meningitis: the situation in Japan where Hib vaccine has not been introduced. J Antimicrob Chemother. 2006;57:1077–1082
  17. Nariai A. Prevalence of β-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae and Haemophilus influenzae type b strains obtained from children with lower respiratory tract infections. J Infect Chemother. 2007;13:396–399

PII: S1201-9712(08)01558-0

doi: 10.1016/j.ijid.2008.09.017

International Journal of Infectious Diseases
Volume 13, Issue 5 , Pages 584-588 , September 2009

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