International Journal of Infectious Diseases
Volume 13, Issue 6 , Pages 707-712 , November 2009

Invasive fungal infections and (1,3)-β-d-glucan serum concentrations in long-term intensive care patients

  • Elisabeth Presterl

      Affiliations

    • Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna - Allgemeines Krankenhaus, Waehringer Guertel 18–20, 1090 Vienna, Austria
    • Corresponding Author InformationCorresponding author. Tel.: +43 1 40400 4440; fax: +43 1 40400 4418.
    • ,
  • Bernhard Parschalk

      Affiliations

    • Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna - Allgemeines Krankenhaus, Waehringer Guertel 18–20, 1090 Vienna, Austria
    • Department of Otorhinology, Medical University of Vienna - Allgemeines Krankenhaus, Vienna, Austria
    • ,
  • Edith Bauer

      Affiliations

    • Department of Medicine III, Division of Nephrology, Medical University of Vienna - Allgemeines Krankenhaus, Vienna, Austria
    • ,
  • Andrea Lassnigg

      Affiliations

    • Department of Anaesthesia and General Intensive Care Medicine, Division of Cardiothoracic Anaesthesia, Medical University of Vienna – Allgemeines Krankenhaus, Vienna, Austria
    • ,
  • Stefan Hajdu

      Affiliations

    • Department of Trauma Surgery, Medical University of Vienna - Allgemeines Krankenhaus, Vienna, Austria
    • ,
  • Wolfgang Graninger

      Affiliations

    • Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna - Allgemeines Krankenhaus, Waehringer Guertel 18–20, 1090 Vienna, Austria

Received 7 January 2008 ,Revised 12 October 2008 ,Accepted 20 October 2008.

References 

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  2. Leleu G, Aegerter P, Guidet B. Systemic candidiasis in intensive care units: a multicenter, matched-cohort study. J Crit Care. 2002;17:168–175
  3. Meersseman W, Vandecasteele SJ, Wilmer A, Verbeken E, Peetermans WE, Van Wijngaerden E. Invasive Aspergillosis in Critically Ill Patients without Malignancy. Am J Respir Crit Care Med. 2004;170:621–625
  4. Yeo SF, Wong B. Current status of nonculture methods for diagnosis of invasive fungal infections. Clin Microbiol Rev. 2002;15:465–484
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  6. Digby J, Kalbfleisch J, Glenn A, Larsen A, Browder W, Williams D. Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients. Clin Diagn Lab Immunol. 2003;10:882–885
  7. Nett J, Lincoln L, Marchillo K, Andes D. Beta-1,3 glucan as a test for central venous catheter biofilm infection. J Infect Dis. 2007;195:1705–1712
  8. Pickering JW, Sant HW, Bowles CA, Roberts WL, Woods GL. Evaluation of a (1→3)-beta-d-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2005;43:5957–5962
  9. Persat F, Ranque S, Derouin F, Michel-Nguyen A, Picot S, Sulahian A. Contribution of the (1→3)-beta-d-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2008;46:1009–1013
  10. Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg. 1994;220:751–758
  11. Leon C, Ruiz-Santana S, Saavedra P, Almirante B, Nolla-Salas J, Alvarez-Lerma F, et al. A bedside scoring system (‘Candida score’) for early antifungal treatment in non-neutropenic critically ill patients with Candida colonization. Crit Care Med. 2006;34:730–737
  12. Bille J, Marchetti O, Calandra T. Changing face of health-care associated fungal infections. Curr Opin Infect Dis. 2005;18:314–319
  13. Yera H, Sendid B, Francois N, Camus D, Poulain D. Contribution of serological tests and blood culture to the early diagnosis of systemic candidiasis. Eur J Clin Microbiol Infect Dis. 2001;20:864–870
  14. Sendid B, Caillot D, Baccouch-Humbert B, Klingspor L, Grandjean M, Bonnin A, et al. Contribution of the Platelia Candida-specific antibody and antigen tests to early diagnosis of systemic Candida tropicalis infection in neutropenic adults. J Clin Microbiol. 2003;41:4551–4558
  15. van Deventer A, van Vliet H, Hop WC, Goessens WH. Diagnostic value of anti-Candida enolase antibodies. J Clin Microbiol. 1994;32:17–23
  16. Odabasi Z, Mattiuzzi G, Estey E, Kantarjian H, Saeki F, Ridge RJ, et al. Beta-d-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis. 2004;39:199–205
  17. Obayashi T, Yoshida M, Mori T, Goto H, Yasuoka A, Iwasaki H, et al. Plasma (1→3)-beta-d-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet. 1995;345:17–20
  18. Ostrosky-Zeichner L, Alexander BD, Kett DH, Vazquez J, Pappas PG, Saeki F, et al. Multicenter clinical evaluation of the (1→3) beta-d-glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis. 2005;41:654–659
  19. Senn L, Robinson JO, Schmidt S, Knaup M, Asahi N, Satomura S, et al. 1,3-Beta-d-glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia. Clin Infect Dis. 2008;46:878–885

PII: S1201-9712(08)01740-2

doi: 10.1016/j.ijid.2008.10.013

International Journal of Infectious Diseases
Volume 13, Issue 6 , Pages 707-712 , November 2009

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