Journal Home
Search for

Volume 14, Issue 1, Pages e22-e27 (January 2010)


View previous. 5 of 18 View next.

Clinical outcomes of HIV-infected patients hospitalized with bacterial community-acquired pneumonia

Maricar Malinisa, John Myersb, Jose BordonacCorresponding Author Informationemail address, Paula Peyrania, Rama Kapoora, Raul Nakamatzua, Gustavo Lopardod, Antoni Torrese, Charles Feldmanf, M. Allena, F. Arnolda, Julio Ramireza

Received 4 November 2008; received in revised form 10 February 2009; accepted 1 March 2009. published online 08 July 2009.

Summary 

Background

There are limited and conflicting data on clinical outcomes of community-acquired pneumonia (CAP) among HIV-infected patients.

Methods

Secondary analyses of clinical outcomes of CAP were performed for 118 patients with HIV infection and 2790 patients without HIV infection enrolled in the Community-Acquired Pneumonia Organization (CAPO) international study. After adjustment for significant confounders, the effect of HIV infection on length of stay (LOS) and time to clinical stability (TCS) were examined by survival analyses and overall mortality and CAP-related mortality by logistic regression methods.

Results

After adjusting for significant confounders, hospitalized HIV-infected patients with CAP did not have longer times to reach clinical stability (HR 1.126; 95% CI 0.917–1.391; p=0.251) or longer stays in the hospital (HR 1.191, 95% CI 0.979–1.449; p=0.080). In addition, HIV infection did not significantly influence overall mortality rates (OR 1.205, 95% CI 0.686–2.116; p=0.517) or CAP-related mortality rates (OR 1.338; 95% CI 0.623–3.725; p=0.355).

Conclusion

The presence of HIV infection did not influence the clinical outcomes of CAP among patients assessed at CAPO centers. It is not intended that our results be extrapolated to populations receiving limited healthcare for advanced HIV disease, malnourishment and parasitic diseases.

Corresponding Editor: Mark Holodniy, California, USA

a Division of Infectious Disease, University of Louisville School of Medicine, Louisville, KY, USA

b School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA

c Department of Medicine, Section of Infectious Diseases, Providence Hospital, 1150 Varnum Street, NE, Washington, DC 20017, USA

d Hospital Benardo Houssay, Buenos Aires, Argentina

e Servei de Pneumologia, Hospital Clinic IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain

f Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa

Corresponding Author InformationCorresponding author. Tel.: +1 202 269 7747; fax: +1 202 269 7892.

PII: S1201-9712(09)00135-0

doi:10.1016/j.ijid.2009.03.001


View previous. 5 of 18 View next.