International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e34-e40 , January 2010

Structured interruptions of highly active antiretroviral therapy in cycles of 4 weeks off/12 weeks on therapy in children having a chronically undetectable viral load cause progressively smaller viral rebounds

  • Gerardo C. Palacios

      Affiliations

    • Departamento de Pediatria and Infectologia Pediatrica, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 25 and Centro de Investigacion Biomedica del Noreste, Instituto Mexicano del Seguro Social, Fidel Velasquez y Lincoln S/N, Colonia Nueva Morelos, Monterrey, Nuevo Leon, CP 64320, Mexico
    • Corresponding Author InformationCorresponding author. Tel.: +52 81 8371 4100x41315; fax: +52 81 8371 4100x41315.
    • ,
  • Luz M. Sanchez

      Affiliations

    • Departamento de Pediatria and Infectologia Pediatrica, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 25 and Centro de Investigacion Biomedica del Noreste, Instituto Mexicano del Seguro Social, Fidel Velasquez y Lincoln S/N, Colonia Nueva Morelos, Monterrey, Nuevo Leon, CP 64320, Mexico
    • ,
  • Evangelina Briones

      Affiliations

    • Coordinacion Delegacional de Investigación en Salud, Instituto Mexicano del Seguro Social, Saltillo, Coahuila, Mexico
    • ,
  • Teresa J. Ramirez

      Affiliations

    • Laboratorio Estatal de Salud Publica del Estado de Nuevo Leon, Secretaria de Salud, Nuevo Leon, Mexico
    • ,
  • Hugo Castillo

      Affiliations

    • Laboratorio Estatal de Salud Publica del Estado de Nuevo Leon, Secretaria de Salud, Nuevo Leon, Mexico
    • ,
  • Lydia G. Rivera

      Affiliations

    • Laboratorio de Inmunologia y Virologia, Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
    • ,
  • Carlos A. Vazquez

      Affiliations

    • Departamento de Pediatria and Infectologia Pediatrica, Unidad Medica de Alta Especialidad, Hospital de Especialidades No. 25 and Centro de Investigacion Biomedica del Noreste, Instituto Mexicano del Seguro Social, Fidel Velasquez y Lincoln S/N, Colonia Nueva Morelos, Monterrey, Nuevo Leon, CP 64320, Mexico
    • ,
  • Cristina Rodriguez-Padilla

      Affiliations

    • Laboratorio de Inmunologia y Virologia, Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
    • ,
  • Mark Holodniy

      Affiliations

    • California, USA
    • Corresponding Author InformationCorresponding author.

Received 5 November 2008 ,Revised 19 February 2009 ,Accepted 1 March 2009.

  • Image Result

    Viral load as the number of copies of viral RNA/ml (filled squares) and the log10 of that number (empty circles) of four HIV-1 infected children in a structured treatment interruption program (STI) in

    Viral load as the number of copies of viral RNA/ml (filled squares) and the log10 of that number (empty circles) of four HIV-1 infected children in a structured treatment interruption program (STI) in cycles of 4 weeks off/12 weeks on HAART. Xn are the 4-week treatment interruption periods. Values correspond to median and quartiles 25 and 75.

  • Image Result
    CD4+ percentage (filled triangles), and CD4+ (empty squares) and CD8+ (empty circles) absolute T lymphocyte counts of four HIV-1 infected children in a structured treatment interruption program (STI)

    CD4+ percentage (filled triangles), and CD4+ (empty squares) and CD8+ (empty circles) absolute T lymphocyte counts of four HIV-1 infected children in a structured treatment interruption program (STI) in cycles of 4 weeks off/12 weeks on HAART. Xn are the 4-week treatment interruption periods. Values correspond to median.

PII: S1201-9712(09)00137-4

doi: 10.1016/j.ijid.2009.03.003

International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e34-e40 , January 2010

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