International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e41-e49 , January 2010

Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic

  • Helen Marshall

      Affiliations

    • School of Paediatrics and Reproductive Health, University of Adelaide and Paediatric Trials Unit, Women's and Children's Hospital, Children, Youth and Women's Health Service, 72 King William Road, North Adelaide SA 5006, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 8 8161 8115; fax: +61 8 8161 7031.
    • ,
  • Peter McIntyre

      Affiliations

    • National Centre for Immunisation Research and Surveillance, University of Sydney and the Children's Hospital at Westmead, New South Wales, Australia
    • ,
  • Don Roberton

      Affiliations

    • School of Paediatrics and Reproductive Health, University of Adelaide and Paediatric Trials Unit, Women's and Children's Hospital, Children, Youth and Women's Health Service, 72 King William Road, North Adelaide SA 5006, Australia
    • ,
  • Leonie Dinan

      Affiliations

    • School of Paediatrics and Reproductive Health, University of Adelaide and Paediatric Trials Unit, Women's and Children's Hospital, Children, Youth and Women's Health Service, 72 King William Road, North Adelaide SA 5006, Australia
    • ,
  • Karin Hardt

      Affiliations

    • GlaxoSmithKline Biologicals, Rixensart, Belgium

Received 8 April 2008 ,Revised 25 November 2008 ,Accepted 2 March 2009.

References 

  1. Australian Government Department of Health and Aging. National Immunisation Program Schedule, November 2005. Available at: http://www.immunise.health.gov.au/internet/immunise/publishing.nsf/Content/nips (accessed April 2009).
  2. Torvaldsen S, Hull BP, McIntyre PB. Using the Australian Childhood Immunisation Register to track the transition from whole-cell to acellular pertussis vaccines. Commun Dis Intell. 2002;26:581–583
  3. Bower C, Condon R, Payne J, Burton P, Watson C, Wild B. Measuring the impact of conjugate vaccines on invasive Haemophilus influenzae type b infection in Western Australia. Aust N Z J Public Health. 1998;22:67–72
  4. Andre FE. Development and clinical application of new polyvalent combined paediatric vaccines. Vaccine. 1999;17:1620–1627
  5. Advisory Committee on Immunization Practices . Combination vaccines for childhood immunization. MMWR Recomm Rep. 1999;48(RR-5):1–14
  6. Dodd D. Benefits of combination vaccines: effective vaccination on a simplified schedule. Am J Manag Care. 2003;9(Suppl):S6–12
  7. Ferson MJ, McKenzie KA, Macartney-Bourne F. Fragmentation of scheduled visits and missed doses among infants receiving multiple injected vaccines. Aust N Z J Public Health. 1997;21:735–738
  8. Usonis V, Bakasenas V, Willems P, Clemens R. Feasibility study of a combined diphtheria–tetanus–acellular pertussis–hepatitis B (DTPa–HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria–tetanus–acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed or injected into separate limbs. Vaccine. 1997;15:1680–1686
  9. Aristegui J, Dal-Re R, Garrote E, Gonzalez A, Arrate JP, Perez A. Assessment of the immunogenicity and reactogenicity of a quadrivalent diphtheria, tetanus, acellular pertussis and hepatitis B (DTPa–HBV) vaccine administered in a single injection with Haemophilus influenzae type b conjugate vaccine, to infants at 2. 4 and 6 months of age. Vaccine. 1998;16:1976–1981
  10. Capiau C, Poolman J, Hoet B, Bogaerts H, Andre F. Development and clinical testing of multivalent vaccines based on a diphtheria–tetanus–acellular pertussis vaccine: difficulties encountered and lessons learned. Vaccine. 2003;21:2273–2287
  11. Gabutti G, Bona G, Dentico P, Bamfi F, Hardt K, Majori S, et al. Immunogenicity and reactogenicity following primary immunisation with a combined DTPa–HBV vaccine and a Haemophilus influenzae type B vaccine administered by separate or mixed injection. Clin Drug Invest. 2005;25:315–323
  12. Omenaca F, Dal-Re R, D’Apuzzo V, Kattamis C, Gnehm HP, Garcia-Sicilia J, et al. Reactogenicity of DTPa–HBV/Hib vaccine administered as a single injection vs. DTPa–HBV and Hib vaccines administered simultaneously at separate sites, to infants at 2, 4 and 6 months of age. Vaccine. 2001;19:4260–4266
  13. Plotkin S, Orenstein W. Vaccines. 4th ed.. Philadelphia, USA: W B Saunders Company; 2003;pp. 240–58
  14. Eskola J, Ward J, Dagan R, Goldblatt D, Zepp F, Siegrist CA. Combined vaccination of Haemophilus influenzae type b conjugate and diphtheria–tetanus–pertussis containing acellular pertussis. Lancet. 1999;354:2063–2068
  15. Poolman J, Kaufhold A, De Grave D, Goldblatt D. Clinical relevance of lower Hib response in DTPa-based combination vaccines. Vaccine. 2001;19:2280–2285
  16. Nolan T, Altman A, Skeljo M, Streeton C, Schuerman L. Antibody persistence, PRP-specific immune memory and booster responses in infants immunised with a combination DTPa–HBV–IPV/Hib vaccine. Vaccine. 2004;23:14–20
  17. Zepp F, Schmitt HJ, Kaufhold A, Schuind A, Knuf M, Habermehl P, et al. Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b-PRP (Hib) boosters children primed with a tetanus–conjugate Hib–DTPa–HBV combined vaccine. Eur J Pediatr. 1997;156:18–24
  18. Dagan R, Amir J, Ashkenazi S, Hardt K, Kaufhold A. Early responses to nonconjugated polyribosylribitol phosphate challenge as evidence of immune memory after combined diphtheria–tetanus–pertussis–polio–Haemophilus influenzae type b primary vaccination. Pediatr Infect Dis J. 2001;20:587–592
  19. Marshall H, Nolan T, Roberton D, Richmond P, Lambert S, Jacquet JM, et al. A comparison of booster immunisation with a combination DTPa–IPV vaccine or DTPa plus IPV in separate injections when co-administered with MMR, at age 4-6 years. Vaccine. 2006;24:6120–6128
  20. Halperin SA, Tapiero B, Law B, Diaz-Mitoma F, Duval B, Langley JM, et al. Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus. Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers. Vaccine. 2006;24:4017–4023
  21. Heininger U; DTP-HBV-IPV-059 Study Group; DTP-HBV-IPV-096 Study Group, Sänger R, Jacquet JM, Schuerman L. Booster immunisation with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate combination vaccine in the second year of life: safety, immunogenicity and persistence of antibody responses. Vaccine 2007; 25:1055-63.
  22. Jacquet JM, Begue P, Grimprel E, Reinert P, Sandbu S, Silverdal SA, et al. Safety and immunogenicity of a combined DTPa–IPV vaccine administered as a booster from 4 years of age: a review. Vaccine. 2006;24:2440–2444
  23. Peltola H, Käyhty H, Virtanen M, Mäkelä PH. Prevention of Haemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine. N Engl J Med. 1984;310:1561–1566
  24. Kayhty H. Difficulties in establishing a serological correlate of protection after immunization with Haemophilus influenzae conjugate vaccines. Biologicals. 1994;22:397–402
  25. Schmitt HJ, Zepp F, Müschenborn S, Sümenicht G, Schuind A, Beutel K, et al. Immunogenicity and reactogenicity of a Haemophilus influenzae type b tetanus conjugate vaccine when administered separately or mixed with concomitant diphtheria–tetanus toxoid and acellular pertussis vaccine for booster immunization. Eur J Pediatr. 1998;157:8–14
  26. Goldblatt D, Richmond P, Millard E, Thornton C, Miller E. The induction of immunologic memory after vaccination with Haemophilus influenzae type b conjugate and acellular pertussis-containing diphtheria, tetanus, and pertussis vaccine combination. J Infect Dis. 1999;180:538–541
  27. Von Kries R, Bohm O, Windfuhr A. Haemophilus influenzae b-vaccination: the urgency for timely vaccination. Eur J Pediatr. 1997;156:282–287
  28. Ramsay ME, McVernon J, Andrews NJ, Heath PT, Slack MP. Estimating Haemophilus influenzae type b vaccine effectiveness in England and Wales by use of the screening method. J Infect Dis. 2003;188:481–485
  29. Kelly DF, Moxon R, Pollard AJ. Haemophilus influenzae type b conjugate vaccines. Immunology. 2004;113:163–174
  30. Schmitt HJ, von Kries R, Hassenpflug B, Hermann M, Siedler A, Niessing W, et al. Haemophilus influenzae type b disease: impact and effectiveness of diphtheria–tetanus toxoids–acellular pertussis (-inactivated poliovirus)/H. influenzae type b combination vaccines. Pediatr Infect Dis J. 2001;20:767–774
  31. Rennels MB. Extensive swelling reactions occurring after booster doses of diphtheria–tetanus–acellular pertussis vaccines. Semin Pediatr Infect Dis. 2003;14:196–198
  32. Marshall H, Gold M, Roberton D, Gent R, Quinn P, Piotto L, et al. Ultrasound examination of extensive limb swelling reactions after diphtheria-tetanus-acellular pertussis or reduced-antigen content diphtheria-tetanus-acellular pertussis immunization in pre-school-aged children. Pediatrics. 2006;118:1–9
  33. Rowe J, Yerkovich ST, Richmond P, Suriyaarachchi D, Fisher E, Feddema L, et al. Th2-associated local reactions to the acellular diphtheria–tetanus–pertussis vaccine in 4- to 6-year-old children. Infect Immun. 2005;73:8130–8135

PII: S1201-9712(09)00138-6

doi: 10.1016/j.ijid.2009.03.004

International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e41-e49 , January 2010

Article Tools

* Image Usage & Resolution