International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e50-e54 , January 2010

Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion?

  • Sener Barut

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpasa University, 60100 Tokat, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 356 212 9500/1207; fax: +90 356 213 3179.
    • ,
  • Fatma Dincer

      Affiliations

    • Intensive Care Unit, Cevdet Aykan State Hospital, Tokat, Turkey
    • ,
  • Idris Sahin

      Affiliations

    • Department of Internal Medicine, Inonu University, Malatya, Turkey
    • ,
  • Huseyin Ozyurt

      Affiliations

    • Department of Biochemistry, Gaziosmanpasa University, Tokat, Turkey
    • ,
  • Mehmet Akkus

      Affiliations

    • Infectious Diseases Clinic, Cevdet Aykan State Hospital, Tokat, Turkey
    • ,
  • Unal Erkorkmaz

      Affiliations

    • Department of Biostatistics, Gaziosmanpasa University, Tokat, Turkey

Received 27 February 2008 ,Revised 6 November 2008 ,Accepted 10 March 2009.

References 

  1. Whitehouse CA. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004;64:145–160
  2. Tasdelen Fisgin N, Fisgin T, Tanyel E, Doganci L, Tulek N, Guler N, et al. Crimean-Congo hemorrhagic fever: five patients with hemophagocytic syndrome. Am J Hematol. 2008;83:73–76
  3. Ergonul O. Crimean-Congo haemorrhagic fever. Lancet Infect Dis. 2006;6:203–214
  4. Fisher-Hoch SP. Lessons from nosocomial viral haemorrhagic fever outbreaks. Br Med Bull. 2005;73–74:123–137
  5. Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood. 2002;99:3505–3516
  6. Emmenegger U, Schaer DJ, Larroche C, Neftel KA. Haemophagocytic syndromes in adults: current concepts and challenges ahead. Swiss Med Wkly. 2005;135:299–314
  7. Janka G, Zur Stadt U. Familial and acquired hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program. 2005;82–88
  8. Karti SS, Odabasi Z, Korten V, Yilmaz M, Sonmez M, Caylan R, et al. Crimean-Congo hemorrhagic fever in Turkey. Emerg Infect Dis. 2004;10:1379–1384
  9. Fisman DN. Hemophagocytic syndromes and infection. Emerg Infect Dis. 2000;6:601–608
  10. Janka GE, Schneider EM. Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol. 2004;124:4–14
  11. Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr. 2007;166:95–109
  12. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124–131
  13. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, et al. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect. 2004;10:1040–1055
  14. Drosten C, Göttig S, Schilling S, Asper M, Panning M, Schmitz H, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol. 2002;40:2323–2330
  15. Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S. The clinical pathology of Crimean-Congo hemorrhagic fever. Rev Infect Dis. 1989;11:S794–800
  16. Cevik MA, Erbay A, Bodur H, Gulderen E, Bastug A, Kubar A, et al. Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality. Int J Infect Dis. 2008;12:374–379
  17. Tonbak S, Aktas M, Altay K, Azkur AK, Kalkan A, Bolat Y, et al. Crimean-Congo hemorrhagic fever virus: genetic analysis and tick survey in Turkey. J Clin Microbiol. 2006;44:4120–4124
  18. Ministry of Health of the Republic of Turkey. Reports of the Department of Communicable and Epidemic Diseases Control [in Turkish]. Ankara, Turkey: Ministry of Health Publications; 2006. Available at: http://www.kirim-kongo.saglik.gov.tr/. (accessed March 2007).
  19. Cagatay A, Kapmaz M, Karadeniz A, Basaran S, Yenerel M, Yavuz S, et al. Haemophagocytosis in a patient with Crimean Congo haemorrhagic fever. J Med Microbiol. 2007;56:1126–1128
  20. Henter JI, Arico M, Elinder G, Imashuku S, Janka G. Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12:417–433
  21. Janka G, Imashuku S, Elinder G, Schneider M, Henter JI. Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12:435–444
  22. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant. 2004;19:141–149
  23. Ergonul O, Tuncbilek S, Baykam N, Celikbas A, Dokuzoguz B. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis. 2006;193:941–944
  24. Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. Cytokine levels in Crimean-Congo hemorrhagic fever. J Clin Virol. 2006;36:272–276
  25. Ergonul O, Celikbas A, Dokuzoguz B, Eren S, Baykam N, Esener H. Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy. Clin Infect Dis. 2004;39:284–287

PII: S1201-9712(09)00144-1

doi: 10.1016/j.ijid.2009.03.009

International Journal of Infectious Diseases
Volume 14, Issue 1 , Pages e50-e54 , January 2010

Article Tools

* Image Usage & Resolution