International Journal of Infectious Diseases
Volume 14, Issue 2 , Pages e158-e160, February 2010

Brucellosis presenting as myelofibrosis: First case report

  • Faris G. Bakri

      Affiliations

    • Department of Medicine, Division of Infectious Diseases, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan
    • Corresponding Author InformationCorresponding author. Tel.: +962 6 5353666x2474; fax: +962 6 5353388.
    • ,
  • Nazzal M. Al-Bsoul

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, Jordan University Hospital, Amman, Jordan
    • ,
  • Ahmad Y. Magableh

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, Jordan University Hospital, Amman, Jordan
    • ,
  • Asem Shehabi

      Affiliations

    • Department of Pathology–Microbiology, Jordan University Hospital, Amman, Jordan
    • ,
  • Musleh Tarawneh

      Affiliations

    • Department of Pathology, Jordan University Hospital, Amman, Jordan
    • ,
  • Azmy M. Al-Hadidy

      Affiliations

    • Department of Radiology, Jordan University Hospital, Amman, Jordan
    • ,
  • Mohammed A. Abu-Fara

      Affiliations

    • Department of Medicine, Division of Infectious Diseases, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan
    • ,
  • Abdallah S. Awidi

      Affiliations

    • Department of Medicine, Division of Hematology and Oncology, Jordan University Hospital, Amman, Jordan

Received 8 January 2009; received in revised form 8 March 2009; accepted 15 March 2009. published online 08 June 2009.

Corresponding Editor: Ziad Memish, Riyadh, Saudi Arabia

Summary 

We describe the case of a 29-year-old woman who presented with pancytopenia and myelofibrosis. Brucella melitensis was identified in her blood. The patient recovered completely with doxycycline and rifampin. A repeat bone marrow biopsy showed hypercellularity without myelofibrosis. Bone marrow findings in cases of pancytopenia due to brucellosis reveal normocellularity, hypercellularity, hemophagocytosis, or granuloma. To our knowledge this is the first report of brucellosis causing myelofibrosis. Brucellosis should be considered as a possible cause of myelofibrosis in endemic areas.

Keywords: Brucella, Pancytopenia, Myelofibrosis, Bone marrow

 

PII: S1201-9712(09)00154-4

doi:10.1016/j.ijid.2009.03.018

International Journal of Infectious Diseases
Volume 14, Issue 2 , Pages e158-e160, February 2010

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