International Journal of Infectious Diseases
Volume 14, Issue 2 , Pages e127-e131 , February 2010

Factors associated with mortality among HIV-infected patients in the era of highly active antiretroviral therapy in southern India

  • N. Kumarasamy

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 44 22542929; fax: +91 44 22542939.
    • ,
  • Kartik K. Venkatesh

      Affiliations

    • Division of Infectious Diseases, Miriam Hospital, Brown University Medical School, Providence, Rhode Island, USA
    • ,
  • Bella Devaleenol

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • ,
  • S. Poongulali

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • ,
  • Tokugha Yephthomi

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • ,
  • A. Pradeep

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • ,
  • Suneeta Saghayam

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    • ,
  • Timothy Flanigan

      Affiliations

    • Division of Infectious Diseases, Miriam Hospital, Brown University Medical School, Providence, Rhode Island, USA
    • ,
  • Kenneth H. Mayer

      Affiliations

    • Division of Infectious Diseases, Miriam Hospital, Brown University Medical School, Providence, Rhode Island, USA
    • ,
  • Suniti Solomon

      Affiliations

    • YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India

Received 31 July 2008 ,Accepted 31 March 2009.

References 

  1. Palella FJ, Baker RK, Moorman AC, Chmiel JS, Wood KC, Brooks JT, et al. HIV Outpatient Study Investigators Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr. 2006;43:27–34
  2. Bonnet F, Morlat P, Chêne G, Mercié P, Neau D, Chossat I, et al. Groupe d’Epidémiologie Clinique du SIDA en Aquitaine (GECSA) Causes of death among HIV-infected patients in the era of highly active antiretroviral therapy, Bordeaux, France, 1998–1999. HIV Med. 2002;3:195–199
  3. Yang C, Huang YF, Hsiao CF, Yeh YL, Liou HR, Hung CC, et al. Trends of mortality and causes of death among HIV-infected patients in Taiwan, 1984–2005. HIV Med. 2008;9:535–543
  4. Krentz H, Kliewer G, Gill MJ. Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003. HIV Med. 2005;6:99–106
  5. Sackoff J, Hanna DB, Pfeiffer MR, Torian LV. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med. 2006;145:397–406
  6. Saraceni V, King BS, Cavalcante SC, Golub JE, Lauria LM, Moulton LH, et al. Tuberculosis as primary cause of death among AIDS cases in Rio de Janeiro, Brazil. Int J Tuberc Lung Dis. 2008;12:769–772
  7. Etard J, Ndiaye I, Thierry-Mieg M, Guèye NF, Guèye PM, Lanièce I, et al. Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study. AIDS. 2007;20:1181–1189
  8. Casseb J, Fonseca LA, Veiga AP, de Almeida A, Bueno A, Ferez AC, et al. AIDS incidence and mortality in a hospital-based cohort of HIV-1-seropositive patients receiving highly active antiretroviral therapy in São Paulo, Brazil. AIDS Patient Care STDS. 2003;17:447–452
  9. Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, Miotti P, et al. Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration; ART Cohort Collaboration (ART-CC) groups Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006;367:817–824
  10. Kumarasamy N, Solomon S, Chaguturu SK, Mahajan AP, Flanigan TP, Balakrishnan P, et al. The safety, tolerability, and effectiveness of generic antiretroviral drug regimens for HIV-infected patients in south India. AIDS. 2003;17:2265–2271
  11. Kumarasamy N, Solomon S, Flanigan TP, Hemalatha R, Thyagarajan SP, Mayer KH. Natural history of human immunodeficiency virus disease in southern India. Clin Infect Dis. 2003;36:79–85
  12. Kumarasamy N, Solomon S, Chaguturu SK, Cecelia AJ, Vallabhaneni S, Flanigan TP, et al. The changing natural history of HIV disease: before and after the introduction of generic antiretroviral therapy in southern India. Clin Infect Dis. 2005;41:1525–1528
  13. Sobhani R, Basavaraj A, Gupta A, Bhave AS, Kadam DB, Sangle SA, et al. Mortality and clinical characteristics of hospitalized adult patients with HIV in Pune, India. Indian J Med Res. 2007;162:116–121
  14. Teja V, Sudha T, Lakshmi V. Causes and pattern of mortality in HIV-infected, hospitalized patients in a tertiary care hospital: a fourteen year study. Indian J Med Sci. 2007;61:555–561
  15. World Health Organization. Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach 2006 revision. Geneva: WHO; 2006. Available at: http://www.who.int/hiv/pub/arv/adult/en/index.html (accessed May 2009).
  16. World Health Organization. Guidelines on co-trimoxazole prophylaxis for HIV-related infections among children, adolescents, and adults in resource-limited settings: recommendations for a public health approach. Available at: http://www.who.int/hiv/pub/guidelines/ctx/en/index.html (accessed May 2009).
  17. Centers for Disease Control and Prevention. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm (accessed May 2009).
  18. Benson CA, Kaplan JE, Masur H, Pau A, Holmes KK CDC, National Institutes of Health, Infectious Diseases Society of America. Treating opportunistic infections among HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of America. MMWR Recomm Rep. 2004;53(RR-15):1–112
  19. Semba R, Shah N, Klein RS, Mayer KH, Schuman P, Gardner LI, et al. Human Immunodeficiency Virus Epidemiology Research Study Group Highly active antiretroviral therapy associated with improved anemia among HIV-infected women. AIDS Patient Care STDS. 2001;15:473–480
  20. Semba R, Shah N, Klein RS, Mayer KH, Schuman P, Vlahov D Human Immunodeficiency Virus Epidemiology Research Study Group. Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women. Clin Infect Dis. 2002;34:260–266
  21. Valdez H, Chowdhry TK, Asaad R, Woolley IJ, Davis T, Davidson R, et al. Changing spectrum of mortality due to human immunodeficiency virus: analysis of 260 deaths during 1995–1999. Clin Infect Dis. 2001;32:1487–1493
  22. Crum N, Riffenburgh RH, Wegner S, Agan BK, Tasker SA, Spooner KM, et al. Triservice AIDS Clinical Consortium. Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras. J Acquir Immune Defic Syndr. 2006;41:194–200
  23. Jain M, Skiest DJ, Cloud JW, Jain CL, Burns D, Berggren RE. Changes in mortality related to human immunodeficiency virus infection: comparative analysis of inpatient deaths in 1995 and in 1999-2000. Clin Infect Dis. 2003;36:1030–1038
  24. Havlir D, Getahun H, Sanne I, Nunn P. Opportunities and challenges for HIV care in overlapping HIV and TB epidemics. JAMA. 2008;300:423–430
  25. Golub J, Saraceni V, Cavalcante SC, Pacheco AG, Moulton LH, King BS, et al. The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil. AIDS. 2007;21:1441–1448
  26. Wang C, Vlahov D, Galai N, Bareta J, Strathdee SA, Nelson KE, et al. Mortality in HIV-seropositive versus -seronegative persons in the era of highly active antiretroviral therapy: implications for when to initiate therapy. J Infect Dis. 2004;190:1046–1054

PII: S1201-9712(09)00192-1

doi: 10.1016/j.ijid.2009.03.034

International Journal of Infectious Diseases
Volume 14, Issue 2 , Pages e127-e131 , February 2010

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