International Journal of Infectious Diseases
Volume 14, Issue 7 , Pages e613-e617 , July 2010

The relationship between Helicobacter pylori genes cagE and virB11 and gastric cancer

  • Valeska Portela Lima

      Affiliations

    • Department of Pathology and Forensic Medicine, Federal University of Ceará, Porangabussu Campus, Alexander Baraúna Street, 949, Fortaleza, Ceará 60183-630, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 85 8805 0432; fax: +55 85 3267 3840.
  • ,
  • Marcos Antonio Pereira de Lima

      Affiliations

    • Department of Pathology and Forensic Medicine, Federal University of Ceará, Porangabussu Campus, Alexander Baraúna Street, 949, Fortaleza, Ceará 60183-630, Brazil
  • ,
  • Márcia Valéria Pitombeira Ferreira

      Affiliations

    • Department of Pathology and Forensic Medicine, Federal University of Ceará, Porangabussu Campus, Alexander Baraúna Street, 949, Fortaleza, Ceará 60183-630, Brazil
  • ,
  • Marcos Aurélio Pessoa Barros

      Affiliations

    • Saint House of Mercy, Fortaleza, Brazil
  • ,
  • Sílvia Helena Barem Rabenhorst

      Affiliations

    • Department of Pathology and Forensic Medicine, Federal University of Ceará, Porangabussu Campus, Alexander Baraúna Street, 949, Fortaleza, Ceará 60183-630, Brazil

Received 17 February 2009 ,Revised 6 September 2009 ,Accepted 8 September 2009.

References 

  1. Covacci A, Telford JL, Gludice GD, Parsonnet J, Rappouli R. Helicobacter pylori virulence and genetic geography. Science. 1999;284:1328–1333
  2. Akopyants NS, Clifton SW, Kersulyte D, Crabtree JE, Youree BE, Reece CA, et al. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol. 1998;28:37–53
  3. Covacci A, Rappuoli R. Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell. J Exp Med. 2000;191:587–592
  4. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A. 1996;93:14648–14653
  5. Segal ED, Lange C, Covacci A, Tompkins LS, Falkow S. Induction of host signal transduction pathways by Helicobacter pylori. Proc Natl Acad Sci U S A. 1997;94:7595–7599
  6. Sozzi M, Tomasini ML, Vindigni C, Zanussi S, Tedeschi R, Basaglia G, et al. Heterogeneity of cag genotypes and clinical outcome of Helicobacter pylori infection. J Lab Clin Med. 2005;146:262–270
  7. Ikenoue T, Maeda S, Ogura K, Akanuma M, Mitsuno Y, Imai Y, et al. Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island. Clin Diagn Lab Immunol. 2001;8:181–186
  8. Krause S, Pansegrau W, Lurz R, de la Cruz F, Lanka E. Enzymology of type IV macromolecule secretion systems: the conjugative transfer regions of plasmids RP4 and R388 and the cag pathogenicity island of Helicobacter pylori encode structurally and functionally related nucleoside triphosphate hydrolases. J Bacteriol. 2000;182:2761–2770
  9. Backert S, Moese S, Selbach M, Brinkmann V, Meyer TF. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol. 2001;42:631–644
  10. Tummuru MK, Sharma SA, Blaser MJ. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol. 1995;18:867–876
  11. Day AS, Jones NL, Lynett JT, Jennings HA, Fallone CA, Beech R, et al. cagE is a virulence factor associated with Helicobacter pylori-induced duodenal ulceration in children. J Infect Dis. 2000;181:1370–1375
  12. Chomvarin C, Namwat W, Chaicumpar K, Mairiang P, Sangchan A, Sripa B, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA and babA2 genotypes in Thai dyspeptic patients. Int J Infect Dis. 2008;12:30–36
  13. Ali M, Khan AA, Tiwari SK, Ahmed N, Rao LV, Habibullah CM. Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer, gastric carcinoma, and non-ulcer dyspepsia subjects with histological changes. World J Gastroenterol. 2005;11:6815–6822
  14. Yamazaki S, Yamakawa A, Okuda T, Ohtani M, Suto H, Ito Y, et al. Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan. J Clin Microbiol. 2005;43:3906–3916
  15. Tan HJ, Rizal AM, Rosmadi MY, Goh KL. Distribution of Helicobacter pylori cagA, cagE and vacA in different ethnic groups in Kuala Lumpur, Malaysia. J Gastroenterol Hepatol. 2005;20:589–594
  16. Tomasini ML, Zanussi S, Sozzi M, Tedeschi R, Basaglia G, De Paoli P. Heterogeneity of cag genotypes in Helicobacter pylori isolates from human biopsy specimens. J Clin Microbiol. 2003;41:976–980
  17. Foster GD, Twell DJ. Plant gene isolation: principles and practice. Chichester, UK: Wiley; 1996;p. 426
  18. Lage AP, Godfroid E, Fauconnier A, Burette A, Butzler JP, Bollen A, et al. Diagnosis of Helicobacter pylori infection by PCR: comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens. J Clin Microbiol. 1995;33:2752–2756
  19. Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet. 1991;338:332–335
  20. Ching CK, Wong BC, Kwok E, Ong L, Covacci A, Lam SK. Prevalence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls. Am J Gastroenterol. 1996;91:949–953
  21. Módena JL, Acrani GO, Micas AF, Castro M, Silveira WD, Módena JL, et al. Correlation between Helicobacter pylori infection, gastric diseases and life habits among patients treated at a university hospital in Southeast Brazil. Braz J Infect Dis. 2007;11:89–95
  22. Miehlke S, Kibler K, Kim JG, Figura N, Small SM, Graham DY, et al. Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol. 1996;91:1322–1325
  23. Graham DY, Genta RM, Graham DP, Crabtree JE. Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. J Clin Pathol. 1996;49:829–832
  24. Pan ZJ, Berg DE, van der Hulst RW, Su WW, Raudonikiene A, Xiao SD, et al. Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J Infect Dis. 1998;178:220–226
  25. Maeda S, Ogura K, Yoshida H, Kanai F, Ikenoue T, Kato N, et al. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut. 1998;42:338–343
  26. Queiroz DM, Soares TF, Rocha GA, Carvalho AS, Lage AP, Mendes EN, et al. Difference in cytotoxin production by Helicobacter pylori strains isolated from adults and children with peptic ulcer. In: Proceedings from Helicobacter pylori: basic mechanisms to clinical cure [abstract 49]. Ottawa, Canada: Axcan Pharma;. 1996;p. 49
  27. Loeb M, Jayaratne P, Jones N, Sihoe A, Sherman P. Lack of correlation between vacuolating cytotoxin activity, cagA gene in Helicobacter pylori, and peptic ulcer disease in children. Eur J Clin Microbiol Infect Dis. 1998;17:653–656
  28. Mitchell HM, Hazell SL, Bohane TD, Hu P, Chen M, Li YY. The prevalence of antibody to CagA in children is not a marker for specific disease. J Pediatr Gastroenterol Nutr. 1999;28:71–75
  29. Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270:17771–17777
  30. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol. 1996;20:241–246
  31. Thomazini CM, Pinheiro NA, Pardini MI, Naresse LE, Rodrigues MA. Helicobacter pylori and gastric cancer: distribution of cagA and vacA genotypes in patients with gastric carcinoma. J Bras Patol Med Lab. 2006;42:25–30
  32. Saribasak H, Salih BA, Yamaoka Y, Sander E. Analysis of Helicobacter pylori genotypes and correlation with clinical outcome in Turkey. J Clin Microbiol. 2004;42:1648–1651
  33. Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991;325:1132–1136
  34. Pereira LP, Waisberg J, André EA, Zanoto A, Mendes Júnior JP, Soares HP. Detection of Helicobacter pylori in gastric cancer. Arq Gastroenterol. 2001;38:240–246
  35. Araujo-Filho I, Brandao-Neto J, Pinheiro LA, Azevedo IM, Freire FH, Medeiros AC. Prevalence of Helicobacter pylori infection in advanced gastric carcinoma. Arq Gastroenterol. 2006;43:288–292
  36. Mangia A, Chiriatti A, Ranieri G, Abbate I, Coviello M, Simone G, et al. H. pylori status and angiogenesis factors in human gastric carcinoma. World J Gastroenterol. 2006;12:5465–5472
  37. Erzin Y, Koksal V, Altun S, Dobrucali A, Aslan M, Erdamar S, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. Helicobacter. 2006;11:574–580
  38. Audibert C, Burucoa C, Janvier B, Fauchère JL. Implication of the structure of the Helicobacter pylori cag pathogenicity island in induction of interleukin-8 secretion. Infect Immun. 2001;69:1625–1629
  39. Lehours P, Ménard A, Dupouy S, Bergey B, Richy F, Zerbib F, et al. Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma. Infect Immun. 2004;72:880–888
  40. Hansen S, Vollset SE, Derakhshan MH, Fyfe V, Melby KK, Aase S, et al. Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut. 2007;56:918–925
  41. Buruk F, Berberoglu U, Pak I, Aksaz E, Celen O. Gastric cancer and Helicobacter pylori infection. Br J Surg. 1993;80:378–379
  42. Smith MG, Hold GL, Tahara E, El-Omar EM. Cellular and molecular aspects of gastric cancer. World J Gastroenterol. 2006;12:2979–2990
  43. Hansson LE, Engstrand L, Nyrén O, Evans DJ, Lindgren A, Bergström R, et al. Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology. 1993;105:1098–1103
  44. Palestro G, Pellicano R, Fronda GR, Valente G, De Giuli M, Soldati T, et al. Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy. World J Gastroenterol. 2005;11:7131–7135
  45. Rogers WM, Dobo E, Norton JA, Van Dam J, Jeffrey RB, Huntsman DG, et al. Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications. Am J Surg Pathol. 2008;32:799–809
  46. Schwarz A. Preventive gastrectomy in patients with gastric cancer risk due to genetic alterations of the E-cadherin gene defect. Langenbecks Arch Surg. 2003;388:27–32
  47. Luo B, Wang Y, Wang XF, Gao Y, Huang BH, Zhao P. Correlation of Epstein–Barr virus and its encoded proteins with Helicobacter pylori and expression of c-met and c-myc in gastric carcinoma. World J Gastroenterol. 2006;12:1842–1848

PII: S1201-9712(09)00370-1

doi: 10.1016/j.ijid.2009.09.006

International Journal of Infectious Diseases
Volume 14, Issue 7 , Pages e613-e617 , July 2010