Guanosine triphosphatases as novel therapeutic targets in tuberculosis

Significance of unique cell wall components of Mycobacterium tuberculosis against the host immune system.

GTPase cycle depicting GTP binding proteins as molecular switch proteins cycling between the active GTP-bound and inactive GDP-bound state.

Role of Rab GTPases in phagosome maturation arrest: recruitment of Rab5 on the phagosome results in the formation of early endosome, but lack of Rab7 blocks its maturation into late endosome, ultimately leading to the inhibition of phagosome lysosome fusion.