International Journal of Infectious Diseases
Volume 14, Issue 8 , Pages e704-e707 , August 2010

Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever

  • Hürrem Bodur

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 5084840; fax: +90 312 3126876.
    • ,
  • Esragül Akıncı

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey
    • ,
  • Pınar Öngürü

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey
    • ,
  • Yavuz Uyar

      Affiliations

    • Department of Virology, Refik Saydam Hifzissihha Center, Ankara, Turkey
    • ,
  • Bilkay Baştürk

      Affiliations

    • Department of Immunology, Gazi University, Ankara, Turkey
    • ,
  • Mustafa Gökhan Gözel

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey
    • ,
  • Bircan Ünal Kayaaslan

      Affiliations

    • Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, 06100 Samanpazarı, Ankara, Turkey

Received 8 September 2009 ,Revised 23 January 2010 ,Accepted 3 February 2010.

References 

  1. Whitehouse CA. Crimean-Congo hemorrhagic fever. Antiviral Res. 2004;64:145–160
  2. Burt FJ, Leman PA, Smith JF, Swanepoel R. The use of a reverse transcription-polymerase chain reaction for the detection of viral nucleic acid in the diagnosis of Crimean-Congo haemorrhagic fever. J Virol Methods. 1998;70:129–137
  3. Centers for Disease Control and Prevention (CDC). Viral hemorrhagic fever: initial management of suspected and confirmed cases. MMWR Morb Mortal Wkly Rep 1983; 32:27S–38S.
  4. Charrel RN, Attoui H, Butenko AM, Clegg JC, Deubel V, Frolova TV, et al. Tick-borne virus diseases of human interest in Europe. Clin Microbiol Infect. 2004;10:1040–1055
  5. Bakir M, Ugurlu M, Dokuzoguz B, Bodur H, Tasyaran MA, Vahaboglu H Turkish CCHF Study Group. Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures. J Med Microbiol. 2005;54:385–389
  6. Schnittler HJ, Feldmann H. Viral hemorrhagic fever—a vascular disease?. Thromb Haemost. 2003;89:967–972
  7. Yapar M, Aydogan H, Pahsa A, Besirbellioglu BA, Bodur H, Basustaoglu AC, et al. Rapid and quantitative detection of Crimean-Congo hemorrhagic fever virus by one-step real-time reverse transcriptase-PCR. Jpn J Infect Dis. 2005;58:358–362
  8. Cevik MA, Erbay A, Bodur H, Gülderen E, Baştuğ A, Kubar A, et al. Clinical and laboratory features of Crimean-Congo hemorrhagic fever: predictors of fatality. Int J Infect Dis. 2008;12:374–379
  9. Karti SS, Odabasi Z, Korten V, Yilmaz M, Sonmez M, Caylan R, et al. Crimean-Congo hemorrhagic fever in Turkey. Emerg Infect Dis. 2004;10:1379–1384
  10. Ergonul O, Tuncbilek S, Baykam N, Celikbas A, Dokuzoguz B. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis. 2006;193:941–944
  11. Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. Cytokine levels in Crimean-Congo hemorrhagic fever. J Clin Virol. 2006;36:272–276
  12. Onguru P, Akgul EO, Akinci E, Yaman H, Kurt YG, Erbay A, et al. High serum levels of neopterin in patients with Crimean-Congo hemorrhagic fever and its relation with mortality. J Infect. 2008;56:366–370
  13. Cevik MA, Erbay A, Bodur H, Eren SS, Akinci E, Sener K, et al. Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever. Clin Infect Dis. 2007;45:e96–100
  14. Akinci E, Yilmaz M, Bodur H, Ongürü P, Bayazit FN, Erbay A, et al. Analysis of lymphocyte subgroups in Crimean-Congo hemorrhagic fever. Int J Infect Dis. 2009;13:560–563
  15. Weber F, Mirazimi A. Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zoonosis. Cytokine Growth Factor Rev. 2008;19:395–404
  16. Bevilacqua MP, Nelson RM, Mannori G, Cecconi O. Endothelial-leukocyte adhesion molecules in human disease. Annu Rev Med. 1994;45:361–378
  17. Bevilacqua MP. Endothelial-leukocyte adhesion molecules. Annu Rev Immunol. 1993;11:767–804
  18. Murgue B, Cassar O, Deparis X. Plasma concentrations of sVCAM-1 and severity of dengue infections. J Med Virol. 2001;65:97–104
  19. Khongphatthanayothin A, Phumaphuti P, Thongchaiprasit K, Poovorawan Y. Serum levels of sICAM-1 and sE-selectin in patients with dengue virus infection. Jpn J Infect Dis. 2006;59:186–188
  20. Koraka P, Murgue B, Deparis X, Van Gorp EC, Setiati TE, Osterhaus AD, et al. Elevation of soluble VCAM-1 plasma levels in children with acute dengue virus infection of varying severity. J Med Virol. 2004;72:445–450
  21. Cardier JE, Rivas B, Romano E, Rothman AL, Perez-Perez C, Ochoa M, et al. Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. Endothelium. 2006;13:335–340
  22. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4–25
  23. Tseng CS, Lo HW, Teng HC, Lo WC, Ker CG. Elevated levels of plasma VEGF in patients with dengue hemorrhagic fever. FEMS Immunol Med Microbiol. 2005;43:99–102
  24. Sathupan P, Khongphattanayothin A, Srisai J, Srikaew K, Poovorawan Y. The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection. Ann Trop Paediatr. 2007;27:179–184
  25. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, et al. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic fever. J Virol. 2007;81:1592–1600
  26. Baugh JA, Bucala R. Macrophage migration inhibitory factor. Crit Care Med. 2002;30:S27–35
  27. Gando S, Nishihira J, Kobayashi S, Morimoto Y, Nanzaki S, Kemmotsu O. Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome. Intensive Care Med. 2001;27:1187–1193
  28. Bozza FA, Gomes RN, Japiassu AM, Soares M, Castro-Faria-Neto HC, Bozza PT, et al. Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis. Shock. 2004;22:309–313
  29. Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, Liu HS, et al. Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg. 2006;74:142–147

PII: S1201-9712(10)02344-1

doi: 10.1016/j.ijid.2010.02.2240

International Journal of Infectious Diseases
Volume 14, Issue 8 , Pages e704-e707 , August 2010

Article Tools

* Image Usage & Resolution