International Journal of Infectious Diseases
Volume 14, Issue 9 , Pages e815-e822 , September 2010

Decrease in CD4+CD25+FoxP3+ Treg cells after pulmonary resection in the treatment of cavity multidrug-resistant tuberculosis

  • Ying E. Wu

      Affiliations

    • Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Wen Guang Peng

      Affiliations

    • Department of Thoracic Medicine, The Third People's Hospital of Shantou City, Guangdong, China
    • ,
  • Ying Mu Cai

      Affiliations

    • Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Gao Zhe Zheng

      Affiliations

    • Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Geng Long Zheng

      Affiliations

    • Guangdong Key Laboratory of Medical Molecular Imaging, Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Jing Hua Lin

      Affiliations

    • Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Su Wei Zhang

      Affiliations

    • Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China
    • ,
  • Ke Li

      Affiliations

    • Department of Preventive Medicine, Shantou University Medical College, Xinling Road 22, Shantou, Guangdong, 515031, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 754 88900445; fax: +86 754 88557562.

Received 21 September 2009 ,Revised 3 February 2010 ,Accepted 6 April 2010.

References 

  1. World Health Organization. WHO report 2009. Global tuberculosis control—epidemiology, strategy, financing. WHO/HTM/TB/2009.411. Geneva: WHO; 2009. Available at: http://www.who.int/tb/publications/global_report/2009/key_points/en/index.html.
  2. World Health Organization. Anti-tuberculosis drug resistance in the world. WHO/HTM/TB/2008.394. Geneva: WHO; 2008. Available at: http://whqlibdoc.who.int/hq/2008/WHO_HTM_TB_2008.394_eng.pdf.
  3. Pomerantz BJ, Cleveland JC, Olson HK, Pomerantz M. Pulmonary resection for multi-drug resistant tuberculosis. J Thorac Cardiovasc Surg 2001; 108:448-53.
  4. Furak J, Trojan I, Szoke T, Tiszlavicz L, Morvay Z, Csada E, et al. Surgical intervention for pulmonary tuberculosis: analysis of indications and perioperative data relating to diagnostic and therapeutic resections. Eur J Cardiothorac Surg 2001; 20:722-7.
  5. Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol. 2001;19:93–129
  6. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–562
  7. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor FoxP3. Science. 2003;299:1057–1061
  8. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005;6:338–344
  9. Guyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A. Regulatory T cells are expanded in blood and disease sites in tuberculosis patients. Am J Respir Crit Care Med. 2006;173:803–810
  10. Hougardy JM, Place S, Hildebrand M, Drowart A, Debrie AS, Locht C, et al. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am J Respir Crit Care Med. 2007;176:409–416
  11. Chiacchio T, Casetti R, Butera O, Vanini V, Carrara S, Girard E, et al. Characterization of regulatory T cells identified as CD4+CD25highCD39+ in patients with active tuberculosis. Clin Exp Immunol 2009; 156:463-70.
  12. Roberts T, Beyers N, Aguirre A, Walzl G. Immunosuppression during active tuberculosis is characterized by decreased interferon-γ production and CD25 expression with elevated forkhead box P3, transforming growth factor-β, and interleukin-4 mRNA levels. J Infect Dis 2007; 195:870-8.
  13. Souilamas R, Riquet M, Barthes FP, Chehab A, Capuani A, Faure E. Surgical treatment of active and sequelar forms of pulmonary tuberculosis. Ann Thorac Surg 2001; 71:443-7.
  14. Stenger S, Modlin RL. T cell mediated immunity to Mycobacterium tuberculosis. Curr Opin Microbiol. 1999;2:89–93
  15. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol. 2005;6:353–360
  16. Mischo K, Markus K, Hans-Willi M, Nouailles G, Bonhagen K, Kamrad T, et al. Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J Immunol 2007; 178:2661-5.
  17. Ribeiro-Rodrigues R, Resende Co T, Rojas R, Toossi Z, Dietze R, Boom WH, et al. A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol. 2006;144:25–34
  18. Mason CM, Porretta E, Zhang P, Nelson S. CD4+ CD25+ transforming growth factor-β-producing T cells are present in the lung in murine tuberculosis and may regulate the host inflammatory response. Clin Exp Immunol 2007; 148:537-45.
  19. Chen XC, Zhou BP, Li MZ, Deng QY, Wu XQ, Le XH, et al. CD4+CD25+FoxP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin Immunol 2007; 123:50-9.

PII: S1201-9712(10)02411-2

doi: 10.1016/j.ijid.2010.04.005

International Journal of Infectious Diseases
Volume 14, Issue 9 , Pages e815-e822 , September 2010

Article Tools

* Image Usage & Resolution