International Journal of Infectious Diseases
Volume 16, Issue 3 , Pages e198-e203 , March 2012

Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

  • Maria G. Guzman

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • Corresponding Author InformationCorresponding author. Tel.: +53 7 2020450; fax: +53 7 2046051.
    • ,
  • Angel Alvarez

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Susana Vazquez

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Mayling Alvarez

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Delfina Rosario

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Otto Pelaez

      Affiliations

    • Provincial Public Health and Epidemiology Center, Havana City, Cuba
    • ,
  • Guillermo Cruz

      Affiliations

    • Municipal Public Health and Epidemiology Center, Miramar, Playa, Havana, Cuba
    • ,
  • Rosmari Rodriguez

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Alequis Pavon

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Annia Gonzalez

      Affiliations

    • Municipal Public Health and Epidemiology Center, Miramar, Playa, Havana, Cuba
    • ,
  • Luis Morier

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Dydie Ruiz

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Gustavo Kouri

      Affiliations

    • Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute, Autopista Novia del Mediodía km 6, PO Box 601, Marianao 13, Havana, Cuba
    • ,
  • Scott B. Halstead

      Affiliations

    • Pediatric Dengue Vaccine Initiative, Bethesda, Maryland, USA

Received 2 August 2010 ,Revised 30 August 2011 ,Accepted 1 September 2011.

References 

  1. Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002;10:100–103
  2. Guzman MG, Kouri G. Dengue: an update. Lancet Infect Dis. 2002;2:33–42
  3. Halstead SB. Observations related to pathogenesis of dengue hemorrhagic fever. VI. Hypotheses and discussion. Yale J Biol Med. 1970;42:350–362
  4. Halstead SB. Dengue virus–mosquito interactions. Annu Rev Entomol. 2008;53:273–291
  5. Halstead SB, O’Rourke EJ. Antibody-enhanced dengue virus infection in primate leukocytes. Nature. 1977;265:739–741
  6. Chareonsirisuthigul T, Kalayanarooj S, Ubol S. Dengue virus (DENV) antibody-dependent enhancement of infection upregulates the production of anti-inflammatory cytokines, but suppresses anti-DENV free radical and pro-inflammatory cytokine production, in THP-1 cells. J Gen Virol. 2007;88:365–375
  7. Kouri GP, Guzman MG, Bravo JR, Triana C. Dengue haemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ. 1989;67:375–380
  8. Guzman MG, Kouri G. Dengue haemorrhagic fever integral hypothesis: confirming observations, 1987–2007. Trans R Soc Trop Med Hyg. 2008;102:522–523
  9. Cantelar de Francisco N, Fernandez A, Albert Molina L, Perez Balbis E. [Survey of dengue in Cuba 1978–1979]. Rev Cubana Med Trop. 1981;33:72–78
  10. Mas P. Dengue fever in Cuba in 1977: some laboratory aspects. PAHO Scientific Publication No. 375. Washington DC: Pan American Health Organization; 1978, p. 40–3.
  11. Guzman MG, Deubel V, Pelegrino JL, Rosario D, Marrero M, Sariol C, et al. Partial nucleotide and amino acid sequences of the envelope and the envelope/nonstructural protein-1 gene junction of four dengue-2 virus strains isolated during the 1981 Cuban epidemic. Am J Trop Med Hyg. 1995;52:241–246
  12. Guzman MG, Kouri GP, Bravo J, Soler M, Vazquez S, Morier L. Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study. Am J Trop Med Hyg. 1990;42:179–184
  13. Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazquez S, et al. Epidemiologic studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol. 2000;152:793–799discussion 804
  14. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis. 2002;6:118–124
  15. Guzman MG, Kouri G, Halstead SB. Do escape mutants explain rapid increases in dengue case-fatality rates within epidemics?. Lancet. 2000;355:1902–1903
  16. Guzman MG, Kouri G, Valdes L, Bravo J, Vazquez S, Halstead SB. Enhanced severity of secondary dengue-2 infections: death rates in 1981 and 1997 Cuban outbreaks. Rev Panam Salud Publica. 2002;11:223–227
  17. Guzman MG, Alvarez M, Rodriguez-Roche R, Bernardo L, Montes T, Vazquez S, et al. Neutralizing antibodies after infection with dengue 1 virus. Emerg Infect Dis. 2007;13:282–286
  18. Sangkawibha N, Rojanasuphot S, Ahandrik S, Viriyapongse S, Jatanasen S, Salitul V, et al. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am J Epidemiol. 1984;120:653–669
  19. Graham RR, Juffrie M, Tan R, Hayes CG, Laksono I, Ma’roef C, et al. A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. studies in 1995–1996. Am J Trop Med Hyg. 1999;61:412–419
  20. Alvarez M, Rodriguez-Roche R, Bernardo L, Vazquez S, Morier L, Gonzalez D, et al. Dengue hemorrhagic fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001–2002. Am J Trop Med Hyg. 2006;75:1113–1117
  21. Alvarez M, Pavón A, Vázquez S, Morier L, Alvarez A, Guzmán M. Secuencias de infección viral asociadas a la fiebre del dengue durante la epidemia de dengue 3 de ciudad de La Habana, 2001–2002. Rev Cubana Med Trop. 2008;60(1):26–30
  22. Gonzalez D, Castro O, Perez J, Martinez E, Vazquez S, Rosario D, et al. Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, dengue 3 epidemic, 2001–2002. Int J Infect Dis. 2005;9:280–285
  23. Guzman MG, Pelaez O, Kouri G, Quintana I, Vazquez S, Penton M, et al. [Final characterization of and lessons learned from the dengue 3 epidemic in Cuba, 2001–2002]. Rev Panam Salud Publica. 2006;19:282–289
  24. Pelaez O, Guzmán MG, Kourí G, Pérez R, Martín JLS, Vázquez S, et al. Dengue 3 epidemic in Havana, 2001. Emerg Infect Dis. 2004;10:219–222
  25. PAHO. Dengue and dengue hemorrhagic fever in the Americas: guidelines for prevention and control. PAHO Scientific Publication Number 548. Washington DC: Pan American Health Organization; 1994.
  26. Fernandez RJ, Vazquez S. Serological diagnosis of dengue by an ELISA inhibition method (EIM). Mem Inst Oswaldo Cruz. 1990;85:347–351
  27. Vazquez S, Saenz E, Huelva G, Gonzalez A, Kouri G, Guzman M. [Detection of IgM against the dengue++ virus in whole blood absorbed on filter paper]. Rev Panam Salud Publica. 1998;3:174–178
  28. Rodriguez-Roche R, Alvarez M, Holmes E. Dengue virus type 3, Cuba, 2000–2002. Emerg Infect Dis. 2005;11:773–774
  29. Vazquez S, Valdes O, Pupo M, Delgado I, Alvarez M, Pelegrino JL, et al. MAC-ELISA and ELISA inhibition methods for detection of antibodies after yellow fever vaccination. J Virol Methods. 2003;110:179–184
  30. Morens DM, Halstead SB, Repik PM, Putvatana R, Raybourne N. Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralization. J Clin Microbiol. 1985;22:250–254
  31. Alvarez M, Rodriguez-Roche R, Bernardo L, Morier L, Guzman M. Improved dengue virus plaque formation on BHK 21 and LLC-MK2 cells: evaluation of some factors. Dengue Bull. 2005;29:49–57
  32. Russell PK, Nisalak A, Sukhavachana P, Vivona S. A plaque reduction test for dengue virus neutralizing antibodies. J Immunol. 1967;99:285–290
  33. Guzman MG, Kouri G, Bravo J, Soler M, Martinez E. Sequential infection as risk factor for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) during the 1981 dengue hemorrhagic Cuban epidemic. Mem Inst Oswaldo Cruz. 1991;86:367
  34. Halstead SB. Etiologies of the experimental dengue of Siler and Simmons. Am J Trop Med Hyg. 1974;23:974–982
  35. Papaevangelou G, Halstead SB. Infections with two dengue viruses in Greece in the 20th century. Did dengue hemorrhagic fever occur in the 1928 epidemic?. J Trop Med Hyg. 1977;80:46–51
  36. Valdes L, Guzman MG, Kouri G, Delgado J, Carbonell I, Cabrera MV, et al. [Epidemiology of dengue and hemorrhagic dengue in Santiago, Cuba 1997]. Rev Panam Salud Publica. 1999;6:16–25
  37. Thai KT, Nga TT, Van Nam N, Phuong HL, Giao PT, Hung le Q, et al. Incidence of primary dengue virus infections in Southern Vietnamese children and reactivity against other flaviviruses. Trop Med Int Health. 2007;12:1553–1557
  38. Vaughn DW. Invited commentary: Dengue lessons from Cuba. Am J Epidemiol. 2000;152:800–803
  39. Gibbons RV, Kalanarooj S, Jarman RG, Nisalak A, Vaughn DW, Endy TP, et al. Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences. Am J Trop Med Hyg. 2007;77:910–913
  40. Bravo JR, Guzman MG, Kouri GP. Why dengue haemorrhagic fever in Cuba? 1. Individual risk factors for dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). Trans R Soc Trop Med Hyg. 1987;81:816–820
  41. Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, et al. Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg. 2001;65:180–183
  42. Sierra Bde L, Kouri G, Guzman MG. Race: a risk factor for dengue hemorrhagic fever. Arch Virol. 2007;152:533–542

PII: S1201-9712(11)00249-9

doi: 10.1016/j.ijid.2011.09.026

International Journal of Infectious Diseases
Volume 16, Issue 3 , Pages e198-e203 , March 2012

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