If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. You will then receive an email that contains a secure link for resetting your password
If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password
The high burden of COVID-19 may have contributed to an increased disease fatality [Au?3].
The association of the case fatality rate with the cumulative incidence of COVID-19 and other factors was evaluated.
The burden of COVID-19 on the health system also needs containment in order to limit mortality.
Objectives: In Italy, the case fatality rate (CFR) of coronavirus disease 2019 (COVID-19) during the first wave of the pandemic showed significant geographic heterogeneity. The aim of this study was to explore the possible association between the CFR and measures of disease burden in the Italian regions using an ecological approach.
Methods: Cumulated regional data for the period February 24 to May 11, 2020 were analysed to assess the association of the CFR with the cumulative incidence of COVID-19 and the ratio between the maximum number of COVID-19 patients in intensive care units (ICU) and ICU beds available before the pandemic (ICU load), adjusting for median age of the patients at disease onset, number of nasopharyngeal swabs performed per confirmed case, and prevalence of chronic diseases .
Results: During the study period, the COVID-19 CFR in the Italian regions ranged between 5.0% and 18.4%. On multivariable regression analysis, the CFR was found to be significantly associated with the cumulative incidence (relative rate (RR) 1.02 per 100 cases/1 million increase), median patient age (RR 1.07 per 1 year increase), and ICU load (RR 1.72, 2.18, and 2.57, for >40–70% vs ≤40%, 70–140% vs ≤40%, and ≥140 vs ≤40%, respectively).
Conclusions: A high burden of COVID-19 may contribute to increased disease fatality, possibly as a result of the increasing demand for care of critically ill patients beyond health system capability.
) reported that a larger availability of hospital beds at the country level was associated with a lower CFR. Indeed, it has been suggested that the increased burden on health care systems caused by the sudden increase in number of cases may have contributed to increase the CFR by reducing the standard of care of affected individuals in need of hospital treatment (
). The aim of this study was to explore the possible association between the CFR and measures of disease burden using an ecological approach.
Italy is administratively divided into 19 regions and two autonomous provinces (PA). On February 24, 2020, the Italian Ministry of Health started a daily collection of new COVID-19 cases, with each region and PA providing the number of deaths, number of hospitalized cases, and number of cases in the intensive care unit (ICU). According to the regional burden of COVID-19 patients, a proportion of ICUs were dedicated to COVID-19 patients, or, where possible, separate areas for COVID-19 patients were created in ICUs where non COVID-19 patients were also admitted (
). In regions with the highest burden during the peak of the first wave of the pandemic, virtually all ICU beds were dedicated to COVID-19 patients, and non COVID-19 patients were transferred outside the region (
). The CFR was calculated as the proportion of individuals who died with confirmed COVID-19 of the total reported cases. The correlation coefficient and univariable and multivariable (backward selection, P = 0.20) negative binomial regression were used to assess the association between the CFR and the following variables: cumulative incidence of COVID-19, as a measure of the overall disease burden; ratio between the maximum number of COVID-19 patients in the ICU and number of ICU beds available before the pandemic (ICU load), as a proxy for the capacity to care for severely ill patients; median age at disease (
); number of SARS-CoV-2 nasopharyngeal swabs performed per COVID-19 case diagnosed, as a proxy for the probability of detecting asymptomatic/mildly symptomatic cases.
All of the variables were considered as continuum measures, except ICU load, which was categorized into three classes according to the distribution in quartiles: ≤40%, >40–70%, 70–140% and ≥140%.
During the period considered, 219 214 cases were reported, with a cumulative incidence of 364 per 100 000 inhabitants. At the regional level, incidence ranged between 58 and 912 per 100 000. Table 1 reports the maximum number of COVID-19 patients in the ICU, the number of ICU beds pre COVID-19, and the ICU load by region; of note, the ICU load varied between a minimum of around 16% and a maximum of 253%.
Table 1Maximum number of COVID-19 patients in the ICU, number of ICU beds pre COVID-19, and ICU load by region
Overall, the CFR was 14%, ranging among regions between 5.0% and 18.4%. Figure 1a shows a positive correlation between the CFR and the cumulative incidence (panel A) (0.72, 95% confidence interval (CI) 0.55 to 0.88, P < 0.01) and the ICU load (panel B) (0.51, 95% CI 0.29 to 0.72, P < 0.01). Figure 1b shows a positive correlation between the CFR and median age at disease onset (panel A) (0.87, 95% CI 0.75 to 0.99, P < 0.01), and a negative correlation between the CFR and the number of swabs per case (panel B) (−0.79, 95% CI −0.88 to −0.81, P < 0.01).
In the univariable analysis, the CFR was associated with the cumulative incidence (relative rate (RR) 1.04 per increase of 100 cases/1 million increase, 95% CI 1.03 to 1.05), ICU load (RR 2.45, 95% CI 1.46 to 4.13 for >40–70% vs ≤40%; RR 9.50, 95% CI 5.65 to 16.00, for 70–140% vs ≤40%; RR 14.19, 95% CI 8.44 to 23.89 for ≥140% vs ≤40%), median age (RR 1.27, 95% CI 1.16 to 1.38 per 1 year increase), and number of nasopharyngeal swabs performed (RR 0.92, 95% CI 0.90 to 0.93 per increase of 1 swab/case), while the prevalence of chronic disease was not associated with the CFR (RR 0.97, 95% CI 0.87 to 1.08 per 1% increase). On multivariable analysis, the cumulative incidence (RR 1.02, 95% CI 1.01 to 1.03 per increase of 100 cases/1 million increase), median age (RR 1.08, 95% CI 1.04 to 1.13 per 1 year increase), and ICU load (RR 1.72, 95% CI 1.31 to 2.27 for >40–70% vs ≤40%; RR 2.18, 95% CI 1.44–3.32 for 70–140% vs ≤40%; RR 2.57, 95% CI 1.57 to 4.21 for ≥140% vs ≤40%) remained significantly associated with the CFR (Table 2).
Table 2Univariable and multivariable analysis of factors associated with the COVID-19 case fatality rate in Italy, February 24 to May 11, 2020
Cumulative incidence (per 100 cases/1 million increase)
Swabs per confirmed case (per 1 swab increase)
Median age at disease (per 1 year increase)
>40–70% vs ≤40%
70–140% vs ≤40%
≥140 % vs ≤40%
Prevalence of chronic disease (per 1% increase)
RR, relative rate; CI, confidence interval; ICU, intensive care unit; NI, not included.
This analysis showed that in Italy, during the first phase of the pandemic, the CFR of COVID-19 at the regional level was significantly associated with the overall burden and ICU demand due to COVID-19, as well as with age at disease onset.
While most previous studies on the variation in CFR of COVID-19 have involved cross-country comparisons, this analysis was conducted in a single country in which health care standards are defined at the national level, thus it is unlikely that regional differences in the overall quality of care may explain the observed differences in the CFR. However, in most severely hit Italian regions, such as Lombardy, the need for hospital care and in particular ICU beds for COVID-19 patients rapidly exceeded the pre-existing capacity (
). The care of critically ill patients with COVID-19 is a complex task in which interventions in several areas are needed. These include infection control practices, hemodynamic and ventilatory support, and COVID-19-specific therapy (
The results of the present study are also consistent with the results of a study conducted in the United States, in which a higher ICU patient load was found to be associated with increased COVID-19 in-hospital mortality (
In a previous study in China, it was observed that Hubei Province, which had the highest COVID-19 incidence during the first wave of the pandemic, also had the highest CFR when compared to the other provinces, and it was postulated that this could be attributed to differences in case ascertainment (
). In the adjusted estimates in the present study, no association was found between the CFR and testing rates, suggesting that it is unlikely that differences in the availability of and approaches to SARS-CoV-2 testing may account for the regional variability in the CFR. Indeed, the testing policy in Italy followed national guidelines, although it is possible that in areas with the highest incidence, even severely ill patients were not tested for SARS-CoV-2, as suggested by the significant numbers of excess deaths recorded in these areas (
A major limitation of this analysis is that the CFR overestimates the true infection fatality rate. Moreover, an ecological approach was used, which is subject to bias due to the lack of individual data (
). It should be noted that the study data were aggregated at a regional level and therefore it was not possible to standardize them by age and sex. Nonetheless, the results of this study are consistent with an analysis of Italian national surveillance data (
). In particular, diseases such as hypertension, heart disease, and diabetes can increase the risk of death by up to three times (Robinson et al., 2021). In our analysis, the prevalence of the population with at least one chronic disease in each region was used, and these data do not seem to show any effect on the CFR . Possible explanations for this finding could be that we used data from all of the population, not adjusted for age, data from a sample survey, and data not specific to particular comorbidities.
In conclusion, this analysis suggests that the rapid increase in incidence of COVID-19 may have contributed to an increased disease fatality. The study findings underscore the need for the timely adoption of mitigation measures during subsequent epidemic waves in order to ensure appropriate care for all affected patients and to limit mortality.
This study was performed with data from routine surveillance activity and did not require ethical clearance.
Conflict of interest
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).