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Original report| Volume 3, ISSUE 4, P181-185, June 1999

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Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam

Open ArchiveDOI:https://doi.org/10.1016/S1201-9712(99)90021-8
Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam
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      Abstract

      Background: The search for the cause of chronic; hepatitis among individuals with non-A to G hepatitis has led to the discovery of a post-transfusion hepatitis-related DNA virus, designated TT virus (TTV), which, based on viral sequences, belongs to a new virus family. The principal modes of infection with TTV are poorly understood, and its role in human immunodeficiency virus type 1 (HIV-1) infection is unclear.
      Objective: To determine if injection drug use (IDU) and high-risk heterosexual activity (HRHA), principal modes of acquiring HIV-1 infection, place individuals at greater risk of acquiring TTV
      Methods: The authors analyzed DNA, extracted from sera or filter paper-blotted whole blood, obtained during August 1997 and June 1998 from 324 Vietnamese (148 male; 176 female), for TTV sequences by hot-start, heminested polymerase chain reaction.
      Results: Prevalence of TTV viremia was similar among individuals engaging in IDU or HRHA (23.4% vs. 20.2%; P > 0.5), with no age- or gender-specific differences. No association was found between TTV viremia and co-infection with HIV-1 or hepatitis C virus (HCV). Phylogenetic analysis of 30 TTV sequences revealed two distinct genotypes and four subtypes that did not segregate according to gender, HIV-1 and HCV risk behaviors, or geographic residence.
      Conclusions: Among HIV-1- or HCV-infected Vietnamese, who presumably acquired their infection by either the parenteral or nonparenteral route, the data indicate no clear association between acquisition of TTV infection and risk behavior for HIV-1 or HCV infection, suggesting that the usual route of TTV transmission in Vietnam is other than parenteral or sexual.

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      Article info

      Publication history

      Accepted: July 13, 1999
      Received: April 30, 1999

      Footnotes

      ☆Presented in part at the 36th Annual Meeting of the Infectious Diseases Society of America, Denver, Colorado, November 12–15,1998, and at the Sixth RCMI International AIDS Symposium, San Juan, Puerto Rico, November 15–17,1998.

      ☆☆Supported by United States Public Health Service grants from the Research Centers in Minority Institutions (RCMI) Program (G12RR/AI03061) and the Fogarty International Center (D43TW00013 and R3TW00866A) of the National Institutes of Health.

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      DOI: https://doi.org/10.1016/S1201-9712(99)90021-8

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