Coronavirus (COVID-19) Collection
Risk Factors Associated with Severe/Critical COVID-19 in People Living with HIV-1Risk factors have been described as associated with severe forms of COVID-19 (Zhang et al., 2020). Persons living with HIV-1 (PLWH1) often carry such comorbidities. As shown by Bhaskaran et al (2021), PLWH1 are at a greater risk of developing a severe form of COVID-19. Our objective was to determine the characteristics associated with the development of a severe or critical form of COVID-19 in a cohort of PLWH1 who were followed up at the Bichat-Claude Bernard University Hospital in Paris, France.
Transient increase in plasma HIV RNA after COVID-19 vaccination with mRNA-1272The latent viral reservoir is the main obstacle preventing HIV eradication, as the virus persists, integrated in long-lived quiescent cells. Immune stimulatory by their nature, vaccines have been evaluated as possible agents for ‘shock and kill’ strategies, which rely on using latency-reversing agents to activate HIV transcription and virion production in order to purge the reservoir.