Coronavirus (COVID-19) Collection
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients
In patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, excessive inflammatory responses are considered to play a major role in the pathogenesis of severe coronavirus disease-2019 (COVID-19) disease, leading to acute respiratory distress syndrome and multiple-organ failure (Moore and June, 2020). Dysregulated inflammatory profile, defective immune responses and lymphopenia have also been identified as important features of severe disease (Del Valle et al., 2020; Bordoni et al., 2020).2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation
On December 31, 2019, aggregate cases of an apparently new respiratory syndrome were reported in the city of Wuhan, China by Chinese national health authorities to the World Health Organization (WHO) (Huang et al., 2020; Organization WH, 2020a). As of 13h February 2020, there have been 45 171 cases reported to the World Health Organization with 1104 deaths (Organization WH, 2020a). Outside China there have been 441 confirmed cases reported from 24 countries (Organization WH, 2020a; Organization WH, 2020b).
