Coronavirus (COVID-19) Collection
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patientsIn patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, excessive inflammatory responses are considered to play a major role in the pathogenesis of severe coronavirus disease-2019 (COVID-19) disease, leading to acute respiratory distress syndrome and multiple-organ failure (Moore and June, 2020). Dysregulated inflammatory profile, defective immune responses and lymphopenia have also been identified as important features of severe disease (Del Valle et al., 2020; Bordoni et al., 2020).
Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variantsGenetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We caracterized how a single mutation in the wildtype sequence of of SARS-CoV-2 could influence the peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles.
2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentationOn December 31, 2019, aggregate cases of an apparently new respiratory syndrome were reported in the city of Wuhan, China by Chinese national health authorities to the World Health Organization (WHO) (Huang et al., 2020; Organization WH, 2020a). As of 13h February 2020, there have been 45 171 cases reported to the World Health Organization with 1104 deaths (Organization WH, 2020a). Outside China there have been 441 confirmed cases reported from 24 countries (Organization WH, 2020a; Organization WH, 2020b).