Coronavirus (COVID-19) Collection
COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case SeriesAs of June 30th, 2021, the ongoing SARS-CoV-2 pandemic has resulted in 180 million COVID-19 cases (with 3.9 million deaths) reported to the World Health Organisation (WHO). Of these, 5.4 million cases with 141,000 deaths have been reported from Africa (WHO Afro 2021). Currently, 150,000 COVID-19 cases have been recorded in Zambia, with 2,100 deaths (WHO COVID-19 dashboard – Zambia 2021).
Post-mortem examination of Hospital Inpatient COVID-19 Deaths in Lusaka, Zambia - A Descriptive Whole-body Autopsy SeriesThe SARS-CoV-2 pandemic has caused 171,292,827 confirmed COVID-19 cases with 3,687,589 deaths globally as of June 4th, 2021. Of these 3,530,845 cases occurred in sub-Saharan Africa (SSA) with 131,630 deaths (WHO Coronavirus dashboard, 2021; Africa CDC - Coronavirus Disease 2019 (COVID-19), 2021). Zambia reported its first COVID-19 case in March 2020 and has since recorded 96, 563 cases with 1,284 deaths as of June 4th, 202 (World Health Organisation, 2021). Eighteen months after the first COVID-19 cases were reported from Wuhan, China, several major knowledge gaps on COVID-19 pathology and pathogenesis remain, particularly in SSA.
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patientsIn patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, excessive inflammatory responses are considered to play a major role in the pathogenesis of severe coronavirus disease-2019 (COVID-19) disease, leading to acute respiratory distress syndrome and multiple-organ failure (Moore and June, 2020). Dysregulated inflammatory profile, defective immune responses and lymphopenia have also been identified as important features of severe disease (Del Valle et al., 2020; Bordoni et al., 2020).
First COVID-19 case in Zambia — Comparative phylogenomic analyses of SARS-CoV-2 detected in African countriesThe WHO declared COVID-19, caused by SARS-CoV-2, a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and later a pandemic on 11 March 2020 (WHO, 2020a). As of 28 September 2020, there were 32.7 million COVID-19 cases with 991,000 deaths worldwide reported to the WHO (2020b). All African countries have been affected and have reported a total of 1,172,342 COVID-19 cases, including 25,481 deaths (WHO, 2020b). As the global COVID-19 events unfolded, and Africa’s first COVID-19 case was reported from Egypt on 14 February 2020, many African countries prepared for the arrival of COVID-19 (Kapata et al., 2020).
2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentationOn December 31, 2019, aggregate cases of an apparently new respiratory syndrome were reported in the city of Wuhan, China by Chinese national health authorities to the World Health Organization (WHO) (Huang et al., 2020; Organization WH, 2020a). As of 13h February 2020, there have been 45 171 cases reported to the World Health Organization with 1104 deaths (Organization WH, 2020a). Outside China there have been 441 confirmed cases reported from 24 countries (Organization WH, 2020a; Organization WH, 2020b).