In South Africa, by the end of the second COVID-19 wave in early February 2021, which driven largely by the Beta variant (501Y.V2), almost 1.5 million COVID-19 cases and 47,000 deaths were recorded (National Institute for Communicable Diseases [NICD], 2021). By the end of September 2021, as South Africa exited the third wave, which was dominated by the Delta variant, just over 2.9 million diagnosed cases and more than 87,000 COVID-19-related deaths were reported (NDoH, 2021). Of these, more than one-third of cases and a quarter of deaths were from the Gauteng Province, the most densely populated province in South Africa, with the City of Johannesburg accounting for almost one-third of diagnosed cases (NDoH, 2021, NICD, 2021).
