Coronavirus (COVID-19) Collection
Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospitalThe emergence and rapid spread of the COVID-19 outbreak, caused by SARS-CoV-2, has become a global health emergency and one of our century's greatest challenges. As of February 24, 2021, approximately 111 million confirmed cases and more than 2.4 million deaths had been reported worldwide (Anon, 2020).
The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patientsIn patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, excessive inflammatory responses are considered to play a major role in the pathogenesis of severe coronavirus disease-2019 (COVID-19) disease, leading to acute respiratory distress syndrome and multiple-organ failure (Moore and June, 2020). Dysregulated inflammatory profile, defective immune responses and lymphopenia have also been identified as important features of severe disease (Del Valle et al., 2020; Bordoni et al., 2020).