Coronavirus (COVID-19) Collection
Workup of cerebral involvement in patients with COVID-19 – authors’ replyWe thank Scorza et al. for their comments on our article (Chen et al., 2022) discussing the new S protein mutation of SARS-CoV-2 and its potential effects on immune regulation, associated with the apparent increase in the incidence of severe neurological symptoms in Taiwanese pediatric patients.
Critical pediatric neurological illness associated with COVID-19 (Omicron BA.2.3.7 variant) infection in Taiwan: immunological assessment and viral genome analysis in tertiary medical centerSince the COVID-19 pandemic outbreak, people all around the world have continued to fight it (Jian et al., 2022). However, as the virus evolves, more variants of concern have been reported (Chung et al., 2022). Patients with COVID-19 infection have also experienced neurological symptoms during the course of the infection (Nordvig et al., 2021). However, severe neurological complications have tended to be more common in children recently (Dilber et al., 2021; Valderas et al., 2022).
Clinical assessment of SARS-CoV-2 antigen rapid detection compared with RT-PCR assay for emerging variants at a high-throughput community testing site in TaiwanA cluster of cases of pneumonia with unknown aetiology was reported and confirmed as 2019-nCoV in 2019 (Wu et al., 2020; Zhu et al., 2020). Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has since spread globally. Reverse transcription polymerase chain reaction (RT-PCR), which is performed to detect viral nucleic acids, is currently considered as the diagnostic gold standard for early diagnosis in patients with suspected SARS-CoV-2 infection (Russo et al., 2020; Safiabadi Tali et al., 2021).
SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performanceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to other RNA viruses, continually mutates, and new variants appear and eventually become dominant. Several SARS-CoV-2 genes have a tendency to evolve, including those encoding the nucleocapsid (N) and spike (S) proteins (Dilucca et al., 2020) [Au?1]. By the end of December 2020, new SARS-CoV-2 variants with multiple accumulated mutations had emerged, and these variants of concern (VOCs) have reportedly been associated with increased transmissibility or decreased effectiveness of available diagnostic tools (Boehm et al., 2021) [Au?1].