Coronavirus (COVID-19) Collection
The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2The avidity of immunoglobulin G (IgG) is determined by its affinity and denotes the strength of binding to its target epitope. High avidity is reached after affinity/avidity maturation and reflects the best fit between IgG and epitope. Avidity of IgG is low during acute infection and reaches high values several weeks or months later (Hedman et al., 1997; Bauer, 2021). Memory B cells express and utilize high avidity IgG to establish effective anamnestic responses (Eisen, 2014).