Coronavirus (COVID-19) Collection
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is characterized by a huge range of clinical manifestations. Many pathogenetic pathways and virulence mechanisms are still unknown. Nevertheless, it is known that the host’s immune system plays a key role (Blanco-Melo et al., 2020). Notably, age, comorbidities (e.g. diabetes mellitus, obesity), smoking habits and male sex (Rod et al., 2020; Wu et al., 2020) are the fundamental independent risk factors for death from coronavirus disease-19 (COVID-19) (Zhou et al., 2020).
- The emergence and rapid spread of the COVID-19 outbreak, caused by SARS-CoV-2, has become a global health emergency and one of our century's greatest challenges. As of February 24, 2021, approximately 111 million confirmed cases and more than 2.4 million deaths had been reported worldwide (Anon, 2020).
- In patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, excessive inflammatory responses are considered to play a major role in the pathogenesis of severe coronavirus disease-2019 (COVID-19) disease, leading to acute respiratory distress syndrome and multiple-organ failure (Moore and June, 2020). Dysregulated inflammatory profile, defective immune responses and lymphopenia have also been identified as important features of severe disease (Del Valle et al., 2020; Bordoni et al., 2020).